ArticleGlycoconjugate journal2004
Recombinant viral sialate-O-acetylesterases.
Article in Glycoconjugate journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- SDAV, the Rat Coronavirus-How Much Do We Know about It in the Light of Potential Zoonoses.Viruses · 2021Review
- SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus-Host Interaction.International journal of molecular sciences · 2020Review
- Review
- Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors.Viruses · 2019Article
- De-O-Acetylation of mucin-derived sialic acids by recombinant NanS-p esterases of Escherichia coli O157:H7 strain EDL933.International journal of medical microbiology : IJMM · 2018Article
- The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human.Microorganisms · 2018Review
- Functions and Biosynthesis of O-Acetylated Sialic Acids.Topics in current chemistry · 2015Review
- Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases.European journal of medicinal chemistry · 2011Article
- O-Acetylated sialic acids and their role in immune defense.Advances in experimental medicine and biology · 2011Article
- Assays of sialate-O-acetyltransferases and sialate-O-acetylesterases.Glycoconjugate journal · 2009Article
- Isolation and properties of two sialate-O-acetylesterases from horse liver with 4- and 9-O-acetyl specificities.Glycoconjugate journal · 2008Article
- Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: new insights for drug discovery.Glycoconjugate journal · 2008Article
- Diversity in cell surface sialic acid presentations: implications for biology and disease.Laboratory investigation; a journal of technical methods and pathology · 2007Review
- Differential surface expression and possible function of 9-O- and 7-O-acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes.Glycoconjugate journal · 2006Article
- Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses.Glycoconjugate journal · 2006Review
- Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue.Glycoconjugate journal · 2006Article
- Sialic acids as receptor determinants for coronaviruses.Glycoconjugate journal · 2006Review
- Luxury at a cost? Recombinant mouse hepatitis viruses expressing the accessory hemagglutinin esterase protein display reduced fitness in vitro.Journal of virology · 2005Article
- Nidovirus sialate-O-acetylesterases: evolution and substrate specificity of coronaviral and toroviral receptor-destroying enzymes.The Journal of biological chemistry · 2005Article
- Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral O-acetylesterases were first identified in several viruses, including influenza C viruses and coronaviruses. These enzymes are capable of removing cellular receptors from the surface of target cells. Hence they are also known as "receptor destroying" enzymes. We have cloned and expressed several recombinant viral O-acetylesterases. These enzymes were secreted from Sf9 insect cells as chimeric proteins fused to eGFP. A purification scheme to isolate the recombinant O-acetylesterase of influenza C virus was developed. The recombinant enzymes derived from influenza C viruses specifically hydrolyze 9-O-acetylated sialic acids, while that of sialodacryoadenitis virus, a rat coronavirus related to mouse hepatitis virus, is specific for 4-O-acetylated sialic acid. The recombinant esterases were shown to specifically de-O-acetylate sialic acids on glycoconjugates. We have also expressed esterase knockout proteins of the influenza C virus hemagglutinin-esterase. The recombinant viral proteins can be used to unambiguously identify O-acetylated acids in a variety of assays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.