ArticleGenetics2004
Sequencing complex diseases With HapMap.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A genetic association study detects haplotypes associated with obstructive heart defects.Human genetics · 2014Article
- Detecting maternal-fetal genotype interactions associated with conotruncal heart defects: a haplotype-based analysis with penalized logistic regression.Genetic epidemiology · 2014Article
- Dynamic modeling of genes controlling cancer stem cell proliferation.Frontiers in genetics · 2012Article
- Modeling haplotype-haplotype interactions in case-control genetic association studies.Frontiers in genetics · 2012Article
- On coding genotypes for genetic markers with multiple alleles in genetic association study of quantitative traits.BMC genetics · 2011Article
- Mapping haplotype-haplotype interactions with adaptive LASSO.BMC genetics · 2010Article
- Article
- Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data.Algorithms for molecular biology : AMB · 2009Article
- Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder.The journal of pain · 2009Article
- Risk haplotype analysis for bovine paratuberculosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- A statistical model for genetic mapping of viral infection by integrating epidemiological behavior.Statistical applications in genetics and molecular biology · 2009Article
- A statistical model for the identification of genes governing the incidence of cancer with age.Theoretical biology & medical modelling · 2008Article
- A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.Molecular pain · 2008Article
- Article
- A general quantitative genetic model for haplotyping a complex trait in humans.Current genomics · 2007Article
- Mapping Nucleotide Sequences that Encode Complex Binary Disease Traits with HapMap.Current genomics · 2007Article
- Prospective health care: the second transformation of medicine.Genome biology · 2006Article
- Theoretical basis for the identification of allelic variants that encode drug efficacy and toxicity.Genetics · 2005Article
- Sequencing drug response with HapMap.The pharmacogenomics journal · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the patterns of DNA sequence variation in the human genome is a useful first step toward identifying the genetic basis of a common disease. A haplotype map (HapMap), aimed at describing these variation patterns across the entire genome, has been recently developed by the International HapMap Consortium. In this article, we present a novel statistical model for directly characterizing specific sequence variants that are responsible for disease risk based on the haplotype structure provided by HapMap. Our model is developed in the maximum-likelihood context, implemented with the EM algorithm. We perform simulation studies to investigate the statistical properties of this disease-sequencing model. A worked example from a human obesity study with 155 patients was used to validate this model. In this example, we found that patients carrying a haplotype constituted by allele Gly16 at codon 16 and allele Gln27 at codon 27 genotyped within the beta2AR candidate gene display significantly lower body mass index than patients carrying the other haplotypes. The implications and extensions of our model are discussed.
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