ArticleGenetics2004
Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience.G3 (Bethesda, Md.) · 2021Article
- Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis inFrontiers in cell and developmental biology · 2021Article
- The Role of Lozenge inMolecules and cells · 2020Review
- Tools Allowing Independent Visualization and Genetic Manipulation ofG3 (Bethesda, Md.) · 2018Article
- Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors.eLife · 2014Article
- Drosophila hematopoiesis: Markers and methods for molecular genetic analysis.Methods (San Diego, Calif.) · 2014Review
- Environment exploration and colonization behavior of the pea aphid associated with the expression of the foraging gene.PloS one · 2013Article
- Genetic screen for regulators of lymph gland homeostasis and hemocyte maturation in Drosophila.G3 (Bethesda, Md.) · 2012Article
- Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons.Cell death and differentiation · 2010Article
- A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.Molecular and cellular biology · 2010Article
- A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections.PLoS biology · 2008Article
- Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos.EMBO reports · 2008Article
- Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection.Genetics · 2008Article
- Early embryonic lethality of mice lacking the essential protein SNEV.Molecular and cellular biology · 2007Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Parallels between vertebrate and Drosophila hematopoiesis add to the value of flies as a model organism to gain insights into blood development. The Drosophila hematopoietic system is composed of at least three classes of terminally differentiated blood cells: plasmatocytes, crystal cells, and lamellocytes. Recent studies have identified transcriptional and signaling pathways in Drosophila involving proteins similar to those seen in human blood development. To identify additional genes involved in Drosophila hematopoiesis, we have conducted a P-element-based genetic screen to isolate mutations that affect embryonic crystal cell development. Using a marker of terminally differentiated crystal cells, we screened 1040 P-element-lethal lines located on the second and third chromosomes and identified 44 individual lines that affect crystal cell development. Identifying novel genes and pathways involved in Drosophila hematopoiesis is likely to provide further insights into mammalian hematopoietic development and disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.