ArticleGenetics2004
Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Article
- A Composite-Likelihood Method for Detecting Incomplete Selective Sweep from Population Genomic Data.Genetics · 2015Article
- Soft shoulders ahead: spurious signatures of soft and partial selective sweeps result from linked hard sweeps.Genetics · 2015Article
- Molecular phylogeography of a human autosomal skin color locus under natural selection.G3 (Bethesda, Md.) · 2013Article
- A selective sweep across species boundaries in Drosophila.Molecular biology and evolution · 2013Article
- Adaptive evolution of multiple traits through multiple mutations at a single gene.Science (New York, N.Y.) · 2013Article
- Statistical inference of selection and divergence from a time-dependent Poisson random field model.PloS one · 2012Article
- Article
- Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world mice.Current biology : CB · 2011Article
- Molecular population genetics of elicitor-induced resistance genes in European aspen (Populus tremula L., Salicaceae).PloS one · 2011Article
- On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.Molecular biology and evolution · 2010Article
- On the origin and spread of an adaptive allele in deer mice.Science (New York, N.Y.) · 2009Article
- Diverse evolutionary histories for beta-adrenoreceptor genes in humans.American journal of human genetics · 2009Article
- Tracking footprints of maize domestication and evidence for a massive selective sweep on chromosome 10.Proceedings of the National Academy of Sciences of the United States of America · 2009Review
- Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains.Applied and environmental microbiology · 2009Article
- Simulation of DNA sequence evolution under models of recent directional selection.Briefings in bioinformatics · 2009Article
- Measuring natural selection on genotypes and phenotypes in the wild.Cold Spring Harbor symposia on quantitative biology · 2009Review
- Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila.Molecular biology and evolution · 2008Article
- Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The recent action of positive selection is expected to influence patterns of intraspecific DNA sequence variation in chromosomal regions linked to the selected locus. These effects include decreased polymorphism, increased linkage disequilibrium, and an increased frequency of derived variants. These effects are all expected to dissipate with distance from the selected locus due to recombination. Therefore, in regions of high recombination, it should be possible to localize a target of selection to a relatively small interval. Previously described patterns of intraspecific variation in three tandemly arranged, testes-expressed genes (janusA, janusB, and ocnus) in Drosophila simulans included all three of these features. Here we expand the original sample and also survey nucleotide polymorphism at three neighboring loci. On the basis of recombination events between derived and ancestral alleles, we localize the target of selection to a 1.5-kb region surrounding janusB. A composite-likelihood-ratio test based on the spatial distribution and frequency of derived polymorphic variants corroborates this result and provides an estimate of the strength of selection. However, the data are difficult to reconcile with the simplest model of positive selection, whereas a new composite-likelihood method suggests that the data are better described by a model in which the selected allele has not yet gone to fixation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.