ArticleGenetics2004
Duplicative and conservative transpositions of larval serum protein 1 genes in the genus Drosophila.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Multiple and diverse structural changes affect the breakpoint regions of polymorphic inversions across the Drosophila genus.Scientific reports · 2016Article
- Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila.Molecular biology and evolution · 2012Article
- Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila.PLoS genetics · 2012Article
- A physical map for an Asian malaria mosquito, Anopheles stephensi.The American journal of tropical medicine and hygiene · 2010Article
- Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps.Genetics · 2008Article
- High incidence of interchromosomal transpositions in the evolutionary history of a subset of or genes in Drosophila.Journal of molecular evolution · 2008Article
- Genome-scale analysis of positionally relocated genes.Genome research · 2007Article
- The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes.BMC molecular biology · 2007Article
- Spliceosomal small nuclear RNA genes in 11 insect genomes.RNA (New York, N.Y.) · 2007Article
- Fast sequence evolution of Hox and Hox-derived genes in the genus Drosophila.BMC evolutionary biology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interspecific comparative molecular analyses of transposed genes and their flanking regions can help to elucidate the time, direction, and mechanism of gene transposition. In the Drosophila melanogaster genome, three Larval serum protein 1 (Lsp1) genes (alpha, beta and gamma) are present and each of them is located on a different chromosome, suggesting multiple transposition events. We have characterized the molecular organization of Lsp1 genes in D. buzzatii, a species of the Drosophila subgenus and in D. pseudoobscura, a species of the Sophophora subgenus. Our results show that only two Lsp1 genes (beta and gamma) exist in these two species. The same chromosomal localization and genomic organization, different from that of D. melanogaster, is found in both species for the Lsp1beta and Lsp1gamma genes. Overall, at least two duplicative and two conservative transpositions are necessary to explain the present chromosomal distribution of Lsp1 genes in the three Drosophila species. Clear evidence for implication of snRNA genes in the transposition of Lsp1beta in Drosophila has been found. We suggest that an ectopic exchange between highly similar snRNA sequences was responsible for the transposition of this gene. We have also identified the putative cis-acting regulatory regions of these genes, which seemingly transposed along with the coding sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.