ArticleGenetics2004
Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- The small GTPase Rho5-Yet another player in yeast glucose signaling.PLoS genetics · 2025Article
- Proteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation.Scientific reports · 2022Article
- Article
- Making Sense of "Nonsense" and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications.International journal of molecular sciences · 2022Review
- Review
- A single NScientific reports · 2018Article
- Nup100 regulatesRNA (New York, N.Y.) · 2017Article
- Systematic engineering of pentose phosphate pathway improvesBiotechnology for biofuels · 2016Article
- Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics.Genes & development · 2015Article
- Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport.Molecular biology of the cell · 2014Article
- Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis.Open biology · 2014Article
- Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae.Genetics · 2013Review
- The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.Genetics · 2013Article
- P-body components, Dhh1 and Pat1, are involved in tRNA nuclear-cytoplasmic dynamics.RNA (New York, N.Y.) · 2011Article
- tRNA biology charges to the front.Genes & development · 2010Review
- Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.Science signaling · 2010Article
- Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae.Molecular biology of the cell · 2010Article
- Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress.Journal of biology · 2007Article
- Inorganic phosphate deprivation causes tRNA nuclear accumulation via retrograde transport in Saccharomyces cerevisiae.Genetics · 2007Article
- Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SOL1, the founding member of the S. cerevisiae SOL family, was previously identified as a multi-copy suppressor of the los1 defect in tRNA-mediated nonsense suppression. Here we report that the four-member SOL family is not essential and that individual family members appear to have distinct functions. SOL1-SOL4 are homologous to genes encoding 6-phosphogluconolactonase (6Pgl) involved in the pentose phosphate pathway. Both Sol3p and Sol4p affect this activity. However, Sol4p does not act as a los1 multi-copy suppressor. In contrast, neither Sol1p nor Sol2p, both of which correct the los1 defect in nonsense suppression, possess detectable 6Pgl activity. Rather, Sol1p and Sol2p appear to function in tRNA nuclear export as sol1 and sol2 mutants possess elevated levels of nuclear tRNA. Members of the Sol protein family appear to have different subcellular distributions. Thus, Sol3p and Sol4p likely function in carbohydrate metabolism, while Sol1p and Sol2p appear to have roles in tRNA function and nuclear export, thereby defining an unusual protein family whose individual members are biochemically distinct and spatially dispersed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.