ArticleBiophysical journal2004
Enforced detachment of red blood cells adhering to surfaces: statics and dynamics.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Shape-Dependent Structural Order of Red Blood Cells.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Characterizing thrombus adhesion strength on common cardiovascular device materials.Frontiers in bioengineering and biotechnology · 2024Article
- Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces.Molecules (Basel, Switzerland) · 2022Article
- Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking.Journal of the Royal Society, Interface · 2022Article
- Holding it together: when cadherin meets cadherin.Biophysical journal · 2021Review
- Curvature-Driven Migration of Colloids on Tense Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Characterizing cell adhesion by using micropipette aspiration.Biophysical journal · 2015Article
- Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells.Scientific reports · 2015Article
- Three functions of cadherins in cell adhesion.Current biology : CB · 2013Review
- Effect of loading conditions on the dissociation behaviour of catch bond clusters.Journal of the Royal Society, Interface · 2012Article
- Tank-treading of swollen erythrocytes in shear flows.Physical review. E, Statistical, nonlinear, and soft matter physics · 2012Article
- Squeezing and detachment of living cells.Biophysical journal · 2010Article
- Monitoring ligand-receptor interactions by photonic force microscopy.Nanotechnology · 2010Article
- Commentary on "Adhesion and membrane tension of single vesicles and living cells using a micropipette-based technique" by M.-J. Colbert et al.The European physical journal. E, Soft matter · 2009Article
- Adhesion and membrane tension of single vesicles and living cells using a micropipette-based technique.The European physical journal. E, Soft matter · 2009Article
- Commentary on "Adhesion and membrane tension of single vesicles and living cells using a micropipette-based technique" by M.-J. Colbert et al.The European physical journal. E, Soft matter · 2009Article
- Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry.Lab on a chip · 2008Article
- Force versus axial deflection of pipette-aspirated closed membranes.Biophysical journal · 2007Article
- Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments.Biophysical journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the mechanical strength of adhesion and the dynamics of unbinding of red blood cells to solid surfaces. Two different situations were tested: 1), native red blood cells nonspecifically adhered to glass surfaces coated with positively charged polymers and 2), biotinylated red blood cells specifically adhered to glass surfaces decorated with streptavidin, which has a high binding affinity for biotin. We used micropipette manipulation for forming and subsequently breaking the adhesive contact through a stepwise micromechanical procedure. Analysis of cell deformations provided the relation between force and contact radius, which was found to be in good agreement with theoretical predictions. We further demonstrated that the separation energy could be precisely derived from the measure of rupture forces and the cell shape. Finally, the dynamics of detachment was analyzed as a function of the applied force and the initial size of the adhesive patch. Our experiments were supported by original theoretical predictions, which allowed us to correlate the measured separation times with the molecular parameters (e.g., activation barrier, receptor-ligand characteristic length) derived from force measurements at the single bond level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.