ArticleBiophysical journal2004
Using the atomic force microscope to study the interaction between two solid supported lipid bilayers and the influence of synapsin I.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Mechanical properties of the high cholesterol-containing membrane: An AFM study.Biochimica et biophysica acta. Biomembranes · 2021Article
- Mechanical Characterization of Liposomes and Extracellular Vesicles, a Protocol.Frontiers in molecular biosciences · 2020Article
- Transient modes of zeolite surface growth from 3D gel-like islands to 2D single layers.Nature communications · 2018Article
- Molecular clutch drives cell response to surface viscosity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Synapsins regulate brain-derived neurotrophic factor-mediated synaptic potentiation and axon elongation by acting on membrane rafts.The European journal of neuroscience · 2017Article
- Direct observation of intermediate states in model membrane fusion.Scientific reports · 2016Article
- Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes.Nature communications · 2015Article
- Penetration of cell membranes and synthetic lipid bilayers by nanoprobes.Biophysical journal · 2014Article
- Article
- Nanomechanics of phospholipid LB film studied layer by layer with AFM.Chemistry Central journal · 2014Article
- Depletion effect and biomembrane budding.Journal of biological physics · 2013Article
- Preparation of DOPC and DPPC Supported Planar Lipid Bilayers for Atomic Force Microscopy and Atomic Force Spectroscopy.International journal of molecular sciences · 2013Article
- Interaction forces between DPPC bilayers on glass.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Natural channel protein inserts and functions in a completely artificial, solid-supported bilayer membrane.Scientific reports · 2013Article
- Overexpression of synapsin Ia in the rat calyx of Held accelerates short-term plasticity and decreases synaptic vesicle volume and active zone area.Frontiers in cellular neuroscience · 2013Article
- Dynamic force spectroscopy on supported lipid bilayers: effect of temperature and sample preparation.Biophysical journal · 2012Article
- Force spectroscopy reveals the effect of different ions in the nanomechanical behavior of phospholipid model membranes: the case of potassium cation.Biophysical journal · 2012Article
- Examining the origins of the hydration force between lipid bilayers using all-atom simulations.The Journal of membrane biology · 2010Article
- Fusion of biomimetic stealth probes into lipid bilayer cores.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Investigation of SNARE-Mediated Membrane Fusion Mechanism Using Atomic Force Microscopy.Japanese journal of applied physics (2008) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To measure the interaction between two lipid bilayers with an atomic force microscope one solid supported bilayer was formed on a planar surface by spontaneous vesicle fusion. To spontaneously adsorb lipid bilayers also on the atomic force microscope tip, the tips were first coated with gold and a monolayer of mercapto undecanol. Calculations indicate that long-chain hydroxyl terminated alkyl thiols tend to enhance spontaneous vesicle fusion because of an increased van der Waals attraction as compared to short-chain thiols. Interactions measured between dioleoylphosphatidylcholine, dioleoylphosphatidylserine, and dioleoyloxypropyl trimethylammonium chloride showed the electrostatic double-layer force plus a shorter-range repulsion which decayed exponentially with a decay length of 0.7 nm for dioleoylphosphatidylcholine, 1.2 nm for dioleoylphosphatidylserine, and 0.8 nm for dioleoyloxypropyl trimethylammonium chloride. The salt concentration drastically changed the interaction between dioleoyloxypropyl trimethylammonium chloride bilayers. As an example for the influence of proteins on bilayer-bilayer interaction, the influence of the synaptic vesicle-associated, phospholipid binding protein synapsin I was studied. Synapsin I increased membrane stability so that the bilayers could not be penetrated with the tip.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.