ArticleBiophysical journal2004
Consequences of molecular-level Ca2+ channel and synaptic vesicle colocalization for the Ca2+ microdomain and neurotransmitter exocytosis: a monte carlo study.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Close agreement between deterministic versus stochastic modeling of first-passage time to vesicle fusion.Biophysical journal · 2022Article
- Influence of T-Bar on Calcium Concentration Impacting Release Probability.Frontiers in computational neuroscience · 2022Article
- A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse.Scientific reports · 2021Article
- A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones.Scientific reports · 2017Article
- Variable priming of a docked synaptic vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The structure and function of 'active zone material' at synapses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling.Channels (Austin, Tex.) · 2015Article
- Quantitative analysis linking inner hair cell voltage changes and postsynaptic conductance change: a modelling study.BioMed research international · 2015Article
- Microdomain calcium fluctuations as a colored noise process.Frontiers in genetics · 2014Article
- An excess-calcium-binding-site model predicts neurotransmitter release at the neuromuscular junction.Biophysical journal · 2013Article
- Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- An ion-insensitive cAMP biosensor for long term quantitative ratiometric fluorescence resonance energy transfer (FRET) measurements under variable physiological conditions.The Journal of biological chemistry · 2011Article
- From the stochasticity of molecular processes to the variability of synaptic transmission.Nature reviews. Neuroscience · 2011Review
- Neuronal plasticity and thalamocortical sleep and waking oscillations.Progress in brain research · 2011Review
- Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.Molecular and cellular neurosciences · 2010Article
- Sensitivity of intracellular calcium-binding sites for exo- and endocytosis of synaptic vesicles to Sr, Ba, and Mg ions.Neuroscience and behavioral physiology · 2010Article
- The organization of the secretory machinery in chromaffin cells as a major factor in modeling exocytosis.HFSP journal · 2010Article
- Monte Carlo simulation of buffered diffusion into and out of a model synapse.Biophysical journal · 2010Article
- Exocytotic dynamics and calcium cooperativity effects in the calyx of Held synapse: a modelling study.Journal of computational neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphological and biochemical studies indicate association between voltage-gated Ca2+ channels and the vesicle docking complex at vertebrate presynaptic active zones, which constrain the separation between some Ca2+ channels and vesicles to 20 nm or less. To address the effect of the precise geometrical relationship among the vesicles, the Ca2+ channel, and the proteins of the release machinery on neurotransmitter release, we developed a Monte Carlo simulation of Ca2+ diffusion and buffering with nanometer resolution. We find that the presence of a vesicle as a diffusion barrier alters the shape of the Ca2+ microdomain of a single Ca2+ channel around the vesicle. This effect is maximal in the vicinity of the vesicle and depends critically on the vesicle's distance from the plasmalemma. Ca2+-sensor(s) for release would be exposed to markedly different [Ca2+], varying by up to 13-fold, depending on their position around the vesicle. As a result, the precise position of Ca2+-sensor(s) with respect to the vesicle and the channel can be critical to determining the release probability. Variation in the position of Ca2+-sensor molecule(s) and their accessibility could be an important source of heterogeneity in vesicle release probability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.