ArticleBiophysical journal2004
Asymmetry in membrane responses to electric shocks: insights from bidomain simulations.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- The Hodgkin-Huxley-Katz Prize Lecture: Heart digital twins: A new paradigm in arrhythmia medicine.The Journal of physiology · 2026Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Validating defibrillation simulation in a human-shaped phantom.Heart rhythm · 2020Article
- Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks.Chaos (Woodbury, N.Y.) · 2017Article
- Bidomain Predictions of Virtual Electrode-Induced Make and Break Excitations around Blood Vessels.Frontiers in bioengineering and biotechnology · 2017Article
- Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.Progress in biophysics and molecular biology · 2016Review
- Mechanism of reentry induction by a 9-V battery in rabbit ventricles.American journal of physiology. Heart and circulatory physiology · 2014Article
- Shock-induced termination of reentrant cardiac arrhythmias: comparing monophasic and biphasic shock protocols.Chaos (Woodbury, N.Y.) · 2013Article
- Efficient simulation of cardiac electrical propagation using high order finite elements.Journal of computational physics · 2012Article
- Computational cardiology: the heart of the matter.ISRN cardiology · 2012Article
- Reversible cardiac conduction block and defibrillation with high-frequency electric field.Science translational medicine · 2011Article
- Modeling defibrillation of the heart: approaches and insights.IEEE reviews in biomedical engineering · 2011Review
- Probing field-induced tissue polarization using transillumination fluorescent imaging.Biophysical journal · 2010Article
- Modeling the role of the coronary vasculature during external field stimulation.IEEE transactions on bio-medical engineering · 2010Article
- Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.American journal of physiology. Heart and circulatory physiology · 2010Article
- Arrhythmogenic mechanisms of the Purkinje system during electric shocks: a modeling study.Heart rhythm · 2009Article
- Towards predictive modelling of the electrophysiology of the heart.Experimental physiology · 2009Review
- Effects of unipolar stimulation on voltage and calcium distributions in the isolated rabbit heart.Basic research in cardiology · 2008Article
- Polarity reversal lowers activation time during diastolic field stimulation of the rabbit ventricles: insights into mechanisms.American journal of physiology. Heart and circulatory physiology · 2008Article
- Evaluating intramural virtual electrodes in the myocardial wedge preparation: simulations of experimental conditions.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Models of myocardial membrane dynamics have not been able to reproduce the experimentally observed negative bias in the asymmetry of transmembrane potential changes (DeltaVm) induced by strong electric shocks delivered during the action potential plateau. The goal of this study is to determine what membrane model modifications can bridge this gap between simulation and experiment. We conducted simulations of shocks in bidomain fibers and sheets with membrane dynamics represented by the LRd'2000 model. We found that in the fiber, the negative bias in DeltaVm asymmetry could not be reproduced by addition of electroporation only, but by further addition of hypothetical outward current, Ia, activated upon strong shock-induced depolarization. Furthermore, the experimentally observed rectangularly shaped positive DeltaVm, negative-to-positive DeltaVm ratio (asymmetry ratio) = approximately 2, electroporation occurring at the anode only, and the increase in positive DeltaVm caused by L-type Ca2+-channel blockade were reproduced in the strand only if Ia was assumed to be a part of K+ flow through the L-type Ca2+-channel. In the sheet, Ia not only contributed to the negative bias in DeltaVm asymmetry at sites polarized by physical and virtual electrodes, but also restricted positive DeltaVm. Inclusion of Ia and electroporation is thus the bridge between experiment and simulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.