ArticleBiophysical journal2004
A model of voltage gating developed using the KvAP channel crystal structure.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Exploring Flexibility and Folding Patterns Throughout Time in Voltage Sensors.Journal of molecular evolution · 2023Article
- Voltage-dependent gating in K channels: experimental results and quantitative models.Pflugers Archiv : European journal of physiology · 2020Review
- Normal mode dynamics of voltage-gated K(+) channels: gating principle, opening mechanism, and inhibition.Journal of computational neuroscience · 2015Article
- Kinetics and thermodynamics of membrane protein folding.Biomolecules · 2014Review
- Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances.Archives of toxicology · 2012Review
- Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.The Journal of biological chemistry · 2011Article
- Down-state model of the voltage-sensing domain of a potassium channel.Biophysical journal · 2010Article
- Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels.Proteins · 2010Article
- Membrane mechanics as a probe of ion-channel gating mechanisms.Physical review. E, Statistical, nonlinear, and soft matter physics · 2008Article
- Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.Biophysical journal · 2008Article
- Models of voltage-dependent conformational changes in NaChBac channels.Biophysical journal · 2008Article
- On the possible methods for the mathematical description of the ball and chain model of ion channel inactivation.Cellular & molecular biology letters · 2008Article
- Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling.Biophysical journal · 2007Article
- Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.Biophysical journal · 2006Article
- Properties of shaker-type potassium channels in higher plants.The Journal of membrane biology · 2006Review
- S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.The Journal of general physiology · 2005Article
- Structural models of TREK channels and their gating mechanism.Channels (Austin, Tex.)Article
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3 authors.
Funding
Abstract
Having inspected the crystal structure of the complete KvAP channel protein, we suspect that the voltage-sensing domain is too distorted to provide reliable information about its native tertiary structure or its interactions with the central pore-forming domain. On the other hand, a second crystal structure of the isolated voltage-sensing domain may well correspond to a native open conformation. We also observe that the paddle model of gating developed from these two structures is inconsistent with many experimental results, and suspect it to be energetically unrealistic. Here we show that the isolated voltage-sensing domain crystal structure can be docked onto the pore domain portion of the full-length KvAP crystal structure in an energetically favorable way to create a model of the open conformation. Using this as a starting point, we have developed rather conventional models of resting and transition conformations based on the helical screw mechanism for the transition from the open to the resting conformation. Our models are consistent with both theoretical considerations and experimental results.
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