ArticleBiophysical journal2004
Models of the structure and voltage-gating mechanism of the shaker K+ channel.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 55 citations in OpenAlex.
- Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels.Channels (Austin, Tex.) · 2023Article
- Challenges and advances in atomistic simulations of potassium and sodium ion channel gating and permeation.The Journal of physiology · 2019Review
- Normal mode dynamics of voltage-gated K(+) channels: gating principle, opening mechanism, and inhibition.Journal of computational neuroscience · 2015Article
- Mechanisms of activation of voltage-gated potassium channels.Acta naturae · 2014Article
- Activity of the calcium channel pore Cch1 is dependent on a modulatory region of the subunit Mid1 in Cryptococcus neoformans.Eukaryotic cell · 2013Article
- Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation.Frontiers in pharmacology · 2012Article
- Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1.European biophysics journal : EBJ · 2011Article
- Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating.Biophysical journal · 2010Article
- Cch1 restores intracellular Ca2+ in fungal cells during endoplasmic reticulum stress.The Journal of biological chemistry · 2010Article
- Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels.Proteins · 2010Article
- Architecture and gating of Hv1 proton channels.The Journal of physiology · 2009Review
- Potassium channel opening: a subtle two-step.The Journal of physiology · 2009Article
- Double bilayers and transmembrane gradients: a molecular dynamics study of a highly charged peptide.Biophysical journal · 2008Article
- Models of voltage-dependent conformational changes in NaChBac channels.Biophysical journal · 2008Article
- Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p.Pflugers Archiv : European journal of physiology · 2008Article
- S0, where is it?The Journal of general physiology · 2008Article
- The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor.Neuron · 2008Article
- Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling.Biophysical journal · 2007Article
- Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments.Eukaryotic cell · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the preceding, accompanying article, we present models of the structure and voltage-dependent gating mechanism of the KvAP bacterial K+ channel that are based on three types of evidence: crystal structures of portions of the KvAP protein, theoretical modeling criteria for membrane proteins, and biophysical studies of the properties of native and mutated voltage-gated channels. Most of the latter experiments were performed on the Shaker K+ channel. Some of these data are difficult to relate directly to models of the KvAP channel's structure due to differences in the Shaker and KvAP sequences. We have dealt with this problem by developing new models of the structure and gating mechanism of the transmembrane and extracellular portions of the Shaker channel. These models are consistent with almost all of the biophysical data. In contrast, much of the experimental data are incompatible with the "paddle" model of gating that was proposed when the KvAP crystal structures were first published. The general folding pattern and gating mechanisms of our current models are similar to some of our earlier models of the Shaker channel.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.