ArticleHistochemistry and cell biology2004
Gender dimorphism influences extracellular matrix expression and regeneration of muscular tissue in mdx dystrophic mice.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Open-Source Tools for Neuromuscular Electrical Stimulation in Mouse Models: A Methodological Validation Study.Muscles (Basel, Switzerland) · 2026Article
- Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity.JCI insight · 2024Article
- The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function.Scientific reports · 2023Article
- Cathelicidin-related antimicrobial peptide mediates skeletal muscle degeneration caused by injury and Duchenne muscular dystrophy in mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Estradiol deficiency reduces the satellite cell pool by impairing cell cycle progression.American journal of physiology. Cell physiology · 2022Article
- Skeletal muscle wasting: the estrogen side of sexual dimorphism.American journal of physiology. Cell physiology · 2022Review
- Extracellular matrix: an important regulator of cell functions and skeletal muscle development.Cell & bioscience · 2021Review
- Mouse Models of Muscle Fibrosis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Impact of estrogen deficiency on diaphragm and leg muscle contractile function in female mdx mice.PloS one · 2021Article
- Article
- The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse.Scientific reports · 2019Article
- Targeting angiogenesis in Duchenne muscular dystrophy.Cellular and molecular life sciences : CMLS · 2019Review
- Effects of metformin on congenital muscular dystrophy type 1A disease progression in mice: a gender impact study.Scientific reports · 2018Article
- Supplementation with a selective amino acid formula ameliorates muscular dystrophy in mdx mice.Scientific reports · 2018Article
- Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner.Genes & nutrition · 2015Article
- Article
- Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials.ILAR journal · 2014Review
- Effects of Dantrolene Therapy on Disease Phenotype in Dystrophin Deficient mdx Mice.PLoS currents · 2013Article
- Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice.Skeletal muscle · 2013Article
- Hormonal receptors in skeletal muscles of dystrophic mdx mice.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mdx mouse, the animal model of Duchenne muscular dystrophy, lacks dystrophin and develops an X-linked recessive inflammatory myopathy characterized by degeneration of skeletal muscle fibers and connective tissue replacement. The present work aimed to assess whether gender dimorphism in mdx mice would influence skeletal muscle pathology at ages corresponding to main histological changes in the microenvironment of muscular tissue: myonecrosis, regeneration, and fibrosis. At the height of myonecrosis (6 weeks postnatal), skeletal muscles of male mdx mice showed increased sarcolemmal permeability, numerous inflammatory foci, and marked deposition of the extracellular matrix components (ECM) type I collagen and laminin. In contrast, age-matched mdx females showed mild ECM deposition, discrete myonecrosis, but increased numbers of regenerating fibers expressing the satellite cell marker NCAM. In contrast ovariectomized mdx females showed decreased numbers of regenerating fibers. Older (24 and 48 weeks postnatal) mdx females showed extensive fibrosis with increased sarcolemmal permeability and marked deposition of ECM components than corresponding males. These results suggest a role for female hormones in the control of myonecrosis probably by promoting regeneration of muscular tissue and mitigating inflammation especially at ages under the critical influence of sex hormones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.