ArticleIntensive care medicine2004
Preferred plasma volume expanders for critically ill patients: results of an international survey.
Article in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function.The Cochrane database of systematic reviews · 2013Pooled it
- Effect of molecular weight and substitution on tissue uptake of hydroxyethyl starch: a meta-analysis of clinical studies.Clinical pharmacokinetics · 2012Pooled it
- The Crystalloid versus Hydroxyethyl Starch Trial: protocol for a multi-centre randomised controlled trial of fluid resuscitation with 6% hydroxyethyl starch (130/0.4) compared to 0.9% sodium chloride (saline) in intensive care patients on mortality.Intensive care medicine · 2011Trial
- Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis.Intensive care medicine · 2011Trial
- Issuing of isotonic crystalloid solutions to Danish public hospitals in 2021-A retrospective nationwide observational study.Acta anaesthesiologica Scandinavica · 2023Observational
- The effect of HES130/0.4 sodium chloride solution on kidney function following early fluid resuscitation in shock patients.Translational andrology and urology · 2021Article
- [Crystalloids and colloids: fluid homeostasis and toxicity].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
- Human albumin solutions in intensive care: A review.Journal of the Intensive Care Society · 2021Review
- Hydroxyethyl starch based smart nanomedicine.RSC advances · 2021Review
- Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union.Frontiers in veterinary science · 2018Review
- Current Trends in Volume Replacement Therapy and the Use of Synthetic Colloids in Small Animals-An Internet-Based Survey (2016).Frontiers in veterinary science · 2017Article
- Fluid resuscitation practice patterns in intensive care units of the USA: a cross-sectional survey of critical care physicians.Perioperative medicine (London, England) · 2016Article
- Resuscitation fluid use in Australian and New Zealand Intensive Care Units between 2007 and 2013.Intensive care medicine · 2015Article
- Volume expansion in the first 4 days of shock: a prospective multicentre study in 19 French intensive care units.Intensive care medicine · 2015Observational
- Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives.Beilstein journal of organic chemistry · 2014Article
- Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?Annals of intensive care · 2013Article
- Effects of synthetic colloids on oxidative stress and inflammatory response in hemorrhagic shock: comparison of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin.Critical care (London, England) · 2013Article
- Effect of intraoperative HES 6% 130/0.4 on the need for blood transfusion after major oncologic surgery: a propensity-matched analysis.Clinics (Sao Paulo, Brazil) · 2013Observational
- Comparison Between the Effects of Ringer`s Lactate and Hydroxyethyl Starch on Hemodynamic Parameters After Spinal Anesthesia: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2013Article
- Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage.Transfusion · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCriteria for plasma volume expander selection in critically ill patients remain controversial. This study evaluated preferences of intensivists regarding plasma volume expanders.
designInternational survey using a 75-item questionnaire. PARTICIPANTS AND
settingAll members of the European and French Societies of Intensive Care Medicine (n=2,415 in 1,610 adult ICUs in Europe and elsewhere) were invited to participate, and 577 (24%) working in 515 ICUs (32%) returned completed questionnaires.
resultsAmong respondents, 17% used crystalloids alone as their first-choice strategy, 18% colloids alone, and 65% both. Colloids alone were often chosen in patients with cirrhosis (42%), coagulation disorders (42%), or adult respiratory distress syndrome (39%); and crystalloids in patients with dehydration (85%), drug overdose (59%), or acute renal failure (49%). First-line plasma expanders were as follows: isotonic crystalloids (81%), starches (55%), gelatins (35%), albumin (7%), plasma (6%), dextrans (4%), and hypertonic crystalloids (2%). Colloids alone were used more frequently in the United Kingdom (40%), starches in Germany (81%) and The Netherlands (66%), and gelatins in the United Kingdom (68%). The main factors behind preferences for first-line plasma volume expanders were time to volume loss correction, duration of effect, adverse events, and cost.
conclusionsColloids are widely used as first-line treatment, usually in combination with crystalloids. Starches are the most widely used colloids in Europe, where albumin use is declining. However, strategies vary widely across clinical situations and countries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.