ArticleProceedings of the National Academy of Sciences of the United States of America2004
Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells.The American journal of pathology · 2026Article
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).European journal of immunology · 2021Review
- Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity.International journal of molecular sciences · 2021Review
- From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics.Clinical and experimental immunology · 2019Review
- A temporally dynamicThe EMBO journal · 2018Article
- Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Mechanisms of diabetic autoimmunity: II--Is diabetes a central or peripheral disorder of effector and regulatory cells?Immunologic research · 2016Review
- Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.Oncotarget · 2016Article
- Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective.Immunology and cell biology · 2016Article
- Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.The Journal of experimental medicine · 2015Article
- Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.Science (New York, N.Y.) · 2015Article
- Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.Immunological reviews · 2014Review
- Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-β and MyD88.Journal of immunology research · 2014Article
- Article
- CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.PloS one · 2012Article
- Low molecular weight fraction secreted by SKOV3 cells expands peripheral CD4+CD25+ regulatory T cells and enhances their suppressive capacity.Medical oncology (Northwood, London, England) · 2010Article
- Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity.The Journal of experimental medicine · 2009Article
- Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection.Journal of virology · 2008Article
- Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness.Current immunology reviews · 2007Article
- Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP.BMC immunology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymectomy at day 3 after birth leads to autoimmune disease in some genetic backgrounds. Disease is thought to be caused by the lack/paucity of regulatory T cells. We show that 3-day-old mice already contain a significant compartment of Foxp3-expressing CD25(+)CD4(+) splenocytes. Whereas, in adult spleen, the subsets of regulatory T cells (CD25(+) and/or CD103(+)) express high amounts of Foxp3 mRNA, in 3-day-old mice, both thymic and splenic CD25(+)CD4(+) T cell subsets express lower amounts of Foxp3 mRNA, and CD103(+) cells are barely detected. In adult day 3-thymectomized mice, the CD25(+)CD4(+) T cell subset is overrepresented (most of the cells being CD103(+)) and expresses high amounts of Foxp3 mRNA, independent of the development of autoimmune gastritis. These cells control inflammatory bowel disease and the homeostatic expansion of lymphocytes. This study demonstrates that the peripheral immune system of newborn mice is endowed of a remarkable regulatory potential, which develops considerably in the absence of thymic supply.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.