ArticleJournal of virology2004
The DNA element controlling expression of the varicella-zoster virus open reading frame 28 and 29 genes consists of two divergent unidirectional promoters which have a common USF site.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Discovering the complete enhancer map of human herpesviruses using a natural language processing model.Nature communications · 2025Article
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- Differential effects of Sp cellular transcription factors on viral promoter activation by varicella-zoster virus (VZV) IE62 protein.Virology · 2015Article
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- Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation.Virology · 2014Article
- Regulation of the varicella-zoster virus ORF3 promoter by cellular and viral factors.Virology · 2013Article
- An Sp1/Sp3 site in the downstream region of varicella-zoster virus (VZV) oriS influences origin-dependent DNA replication and flanking gene transcription and is important for VZV replication in vitro and in human skin.Journal of virology · 2012Article
- A sequence within the varicella-zoster virus (VZV) OriS is a negative regulator of DNA replication and is bound by a protein complex containing the VZV ORF29 protein.Journal of virology · 2011Article
- Role of the IE62 consensus binding site in transactivation by the varicella-zoster virus IE62 protein.Journal of virology · 2010Article
- Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication.Journal of virology · 2008Article
- Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation.Journal of virology · 2008Article
- Cellular and viral factors regulate the varicella-zoster virus gE promoter during viral replication.Journal of virology · 2007Article
- The ubiquitous cellular transcriptional factor USF targets the varicella-zoster virus open reading frame 10 promoter and determines virulence in human skin xenografts in SCIDhu mice in vivo.Journal of virology · 2007Article
- Absence or overexpression of the Varicella-Zoster Virus (VZV) ORF29 latency-associated protein impairs late gene expression and reduces VZV latency in a rodent model.Journal of virology · 2007Article
- Posttranslational modification and cell type-specific degradation of varicella-zoster virus ORF29p.Journal of virology · 2006Article
- Promoter activation by the varicella-zoster virus major transactivator IE62 and the cellular transcription factor USF.Journal of virology · 2006Article
- The cellular localization pattern of Varicella-Zoster virus ORF29p is influenced by proteasome-mediated degradation.Journal of virology · 2006Article
- Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.Journal of bacteriology · 2006Article
- Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene.The Biochemical journal · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism of the divergent expression of the varicella-zoster virus (VZV) ORF 28 and ORF 29 genes from a common intergenic DNA element, the ORF 28/29 promoter, is of interest based on the observation that both genes are expressed during VZV lytic infection but only the ORF 29 gene is expressed in latently infected neurons. In the work presented here, expression driven by the ORF 28/29 intergenic region was examined. We found that the promoter activity towards the ORF 29 direction is more responsive to activation by the major viral transactivator IE62 than that towards the ORF 28 direction in the context of our experimental system. Analysis of the functional DNA elements involved in IE62 activation of the bidirectional ORF 28/29 regulatory element revealed that in both transfected and VZV-superinfected cells it is a fusion of two unidirectional promoters overlapping an essential USF binding site but with distinct TATA elements. A single TATA element directs expression in the ORF 28 direction, whereas the two TATA elements directing ORF 29 gene expression are alternatively and differentially utilized for transcription initiation. We also identified an Sp1 site localized proximal to the ORF 28 gene which functions as an activator element for expression in both directions. These results indicate that the ORF 28 and ORF 29 genes can be expressed either coordinately or independently and that the observed expression of only the ORF 29 gene during VZV latency may involve neuron-specific cellular factors and/or structural aspects of the latent viral genome.
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