ArticleJournal of clinical pathology2004
The homeodomain protein CDX2 is an early marker of Barrett's oesophagus.
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 103 citations in OpenAlex.
- Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy.Journal of gastroenterology · 2024Article
- Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system.iScience · 2022Review
- Review
- Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.Cancer cell · 2018Article
- High yield reproducible rat model recapitulating human Barrett's carcinogenesis.World journal of gastroenterology · 2017Article
- Article
- Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett's Esophagus.American journal of human genetics · 2016Article
- A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia.Oncotarget · 2015Article
- Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid.Clinical and experimental medicine · 2015Article
- TissueCypher(™): A systems biology approach to anatomic pathology.Journal of pathology informatics · 2015Article
- Risk factors associated with Barrett's epithelial dysplasia.World journal of gastroenterology · 2014Article
- Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus.Digestive diseases and sciences · 2014Article
- Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study.Surgical endoscopy · 2012Article
- Clinical implications of molecular changes in pediatric Barrett's esophagus.Current gastroenterology reports · 2012Review
- Math1/Atoh1 contributes to intestinalization of esophageal keratinocytes by inducing the expression of Muc2 and Keratin-20.Digestive diseases and sciences · 2012Article
- Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett's esophagus.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Molecular mechanisms of Barrett's esophagus.Digestive diseases and sciences · 2011Review
- NF-κB is activated in oesophageal fibroblasts in response to a paracrine signal generated by acid-exposed primary oesophageal squamous cells.International journal of experimental pathology · 2011Article
- Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Barrett's oesophagus (BO), squamous epithelium is replaced by specialised intestinal epithelium (SIE). Transcription factors associated with intestinal differentiation, such as CDX2, may be involved in BO development.
aimTo investigate CDX2 expression in BO, squamous epithelium, and oesophageal adenocarcinoma (ADC).
methodsCDX2 expression was assessed in 245 samples-167 biopsies of the columnar lined segment and 38 squamous epithelial biopsies of 39 patients with histologically confirmed BO (10 with ADC). Forty biopsies from 20 patients with reflux oesophagitis (RO) without BO were also evaluated. CDX2 protein was investigated immunohistochemically in 138 biopsies from 16 patients with BO, four with ADC, and 20 with RO. Cdx2 and Muc2 mRNA were detected semiquantitatively using 88 BO biopsies and squamous epithelium from 19 BO patients, and when present from ADC.
resultsSIE was present in 53/79 biopsies from the columnar lined segment; CDX2 protein was seen in all epithelial cells, but not in biopsies containing only gastric metaplastic epithelium (26/79), or in squamous epithelium (0/40) of patients with RO. Cdx2 mRNA was detected in all biopsies with goblet cell specific Muc2 transcription-indicative of SIE. Low Cdx2 mRNA expression was seen in 6/19 squamous epithelium samples taken 5 cm above the squamocolumnar junction of BO patients.
conclusionCDX2 protein/mRNA is strongly associated with oesophageal SIE. Cdx2 mRNA was present in the normal appearing squamous epithelium of one third of BO patients, and may precede morphological changes seen in BO. Therefore, pathways that induce Cdx2 transcription in squamous epithelial cells may be important in BO development.
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