ArticleThe Journal of cell biology2004
Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
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- The expression of REG 1A and REG 1B is increased during acute amebic colitis.Parasitology international · 2011Article
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- Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.Gastroenterology · 2010Article
- Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation.The Journal of biological chemistry · 2009Article
- Role of integrins in the assembly and function of hensin in intercalated cells.Journal of the American Society of Nephrology : JASN · 2008Article
- Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro.Molecular biology of the cell · 2007Article
- Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.BMC developmental biology · 2007Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Single-layered epithelia are the first differentiated cell types to develop in the embryo, with columnar and squamous types appearing immediately after blastocyst implantation. Here, we show that mouse embryonic stem cells seeded on hensin or laminin, but not fibronectin or collagen type IV, formed hemispheric epithelial structures whose outermost layer terminally differentiated to an epithelium that resembled the visceral endoderm. Hensin induced columnar epithelia, whereas laminin formed squamous epithelia. At the egg cylinder stage, the distal visceral endoderm is columnar, and these cells begin to migrate anteriorly to create the anterior visceral endoderm, which assumes a squamous shape. Hensin expression coincided with the dynamic appearance and disappearance of columnar cells at the egg cylinder stage of the embryo. These expression patterns, and the fact that hensin null embryos (and those already reported for laminin) die at the onset of egg cylinder formation, support the view that hensin and laminin are required for terminal differentiation of columnar and squamous epithelial phenotypes during early embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.