ArticleCirculation2004
Maternal calcium intake and offspring blood pressure.
Article in Circulation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006404 (Nutrition in Pregnancy, Birth Weight, and Childhood Asthma), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutrition in Pregnancy, Birth Weight, and Childhood Asthma
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Calcium supplementation during pregnancy and long-term offspring outcome: a systematic literature review and meta-analysis.Annals of the New York Academy of Sciences · 2022Pooled it
- Effect of maternal calcium intake during pregnancy on children's blood pressure: a systematic review of the literature.BMC pediatrics · 2007Pooled it
- Transgression of planetary boundaries and the effects on child health through an infectious diseases lens.Current opinion in pediatrics · 2025Review
- Associations of Prenatal Dietary Inflammatory Potential with Childhood Respiratory Outcomes in Project Viva.The journal of allergy and clinical immunology. In practice · 2020Article
- Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence.Scientific reports · 2018Article
- Association of vitamin E intake at early childhood with alanine aminotransferase levels at mid-childhood.Hepatology (Baltimore, Md.) · 2018Article
- Dietary Inflammatory Potential during Pregnancy Is Associated with Lower Fetal Growth and Breastfeeding Failure: Results from Project Viva.The Journal of nutrition · 2016Observational
- A systematic review on the effects of maternal calcium supplementation on offspring's blood pressure.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Cohort profile: project viva.International journal of epidemiology · 2015Observational
- The effect of supplementary calcium on blood pressure in healthy adult women aged 18-30 years in Tehran, Iran.Journal of education and health promotion · 2015Article
- Article
- Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity.JAMA pediatrics · 2013Article
- Article
- Early influences on cardiovascular and renal development.European journal of epidemiology · 2010Review
- Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children.The American journal of clinical nutrition · 2010Article
- Prospective association between milk intake and adiposity in preschool-aged children.Journal of the American Dietetic Association · 2010Article
- Nutritional programming of disease: unravelling the mechanism.Journal of anatomy · 2009Review
- Maternal calcium intake during pregnancy and blood pressure in the offspring at age 3 years: a follow-up analysis of the Project Viva cohort.American journal of epidemiology · 2008Article
- Fetal nutritional origins of adult diseases: challenges for epidemiological research.European journal of epidemiology · 2008Article
- Diet during pregnancy and risk of preeclampsia or gestational hypertension.Annals of epidemiology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFew data exist on the intergenerational influence of calcium intake during pregnancy on offspring blood pressure. METHODS AND
resultsAs part of the ongoing US prospective cohort study Project Viva, we analyzed 4091 Dinamap blood pressure measurements from 936 six-month-old infants whose mothers had completed food frequency questionnaires during the second trimester of pregnancy. We used mixed models to estimate effects of maternal calcium intake on offspring systolic blood pressure. Mean+/-SD daily total maternal calcium intake was 1494+/-523 mg, consisting of 1230+/-486 mg from foods and 264+/-191 mg from supplements. Mean+/-SD 6-month blood pressure was 89.9+/-12.9 mm Hg. From bottom to top quartile of dietary calcium from foods adjusted for energy intake and measurement conditions, mean infant systolic blood pressures were 91.0, 90.2, 90.9, and 90.2 mm Hg (trend P=0.62). From calcium supplements only, the values were 91.5, 90.2, 90.4, and 88.4 mm Hg (trend P=0.006). After further adjustment for demographic, anthropometric, dietary, social, and economic variables, the decrease in 6-month systolic blood pressure was -3.0 mm Hg (95% CI, -4.9 to -1.1) for each 500-mg increment of maternal supplemental calcium intake during pregnancy. We did not find evidence of effect modification by maternal vitamin D or potassium intake or by infant body mass index. First-trimester calcium intake was not associated with offspring blood pressure.
conclusionsThese observational data suggest that supplementing maternal midgestational calcium intake may lower offspring blood pressure, thus helping to prevent hypertension in the next generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.