ArticleBiochemical and biophysical research communications2004
Immediate early gene X-1 interacts with proteins that modulate apoptosis.
Article in Biochemical and biophysical research communications, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B.iScience · 2020Article
- Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy.International journal of molecular sciences · 2017Article
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- Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Review
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- ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response.Cell death and differentiation · 2010Article
- Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome.International journal of hematology · 2009Article
- HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression.Retrovirology · 2009Article
- High ambient glucose augments angiotensin II-induced proinflammatory gene mRNA expression in human mesangial cells: effects of valsartan and simvastatin.American journal of nephrology · 2009Article
- Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.Journal of the American Society of Nephrology : JASN · 2008Article
- BAT3 interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cells.The Journal of biological chemistry · 2008Article
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.Genes & development · 2007Article
- Phenotype-based identification of host genes required for replication of African swine fever virus.Journal of virology · 2006Article
- The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development.Molecular and cellular biology · 2005Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Immediate early gene X-1 (IEX-1) modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia. To determine how IEX-1 alters apoptosis, we performed yeast two-hybrid studies using IEX-1 as the "bait" protein, and examined interactions between IEX-1 and proteins expressed by a human kidney cDNA expression library. We found that IEX-1 interacts with several proteins of which at least four are known to play a role in the regulation of apoptosis: (1) calcium-modulating cyclophilin ligand; (2) tumor necrosis factor-related apoptosis-inducing ligand (tumor necrosis factor superfamily, member 10); (3) ML-1 myeloid cell leukemia gene encoded protein; and (4) BAT3, a gene present in the major histo-compatibility complex. Our data suggest that IEX-1 may regulate apoptosis by directly interacting with various proteins involved in the control of apoptotic pathways.
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