ArticleAmerican journal of human genetics2004
Family-based association study of synapsin II and schizophrenia.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.Biology · 2026Review
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- Identifying novel associations in GWAS by hierarchical Bayesian latent variable detection of differentially misclassified phenotypes.BMC bioinformatics · 2020Article
- Membrane trafficking in health and disease.Disease models & mechanisms · 2020Review
- Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants.The international journal of neuropsychopharmacology · 2019Article
- The Role of Synapsins in Neurological Disorders.Neuroscience bulletin · 2018Review
- Placebo, nocebo, and neuropathic pain.Pain · 2016Review
- Role of presynaptic phosphoprotein synapsin II in schizophrenia.World journal of psychiatry · 2015Article
- Nitric oxide synthase 1 adaptor protein, a protein implicated in schizophrenia, controls radial migration of cortical neurons.Biological psychiatry · 2015Article
- Synapsin II gene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder: effect of lifetime intake of antipsychotic drugs.The pharmacogenomics journal · 2014Article
- SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth.Human molecular genetics · 2014Article
- H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression.The international journal of neuropsychopharmacology · 2013Article
- Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.Molecular psychiatry · 2012Article
- Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics.European archives of psychiatry and clinical neuroscience · 2012Article
- Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.PloS one · 2012Article
- Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder.PloS one · 2012Article
- Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Current topics in behavioral neurosciences · 2012Review
- Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients.Molecular psychiatry · 2011Article
- Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach.Brain research · 2010Article
- Synapsins are late activity-induced genes regulated by birdsong.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapsin II has been proposed as a candidate gene for vulnerability to schizophrenia on the basis of its function and its location in a region of the genome implicated by linkage studies in families with schizophrenia. We recently reported positive association of synapsin II with schizophrenia in a case-control study (Chen et al. 2004). However, since case-control analyses can generate false-positive results in the presence of minor degrees of population stratification, we have performed a replication study in 366 additional Han Chinese probands and their parents by use of analyses of transmission/disequilibrium for three in/del markers and three single-nucleotide polymorphisms. Positive association was observed for rs2307981 (P =.02), rs2308169 (P =.005), rs308963 (P =.002), rs795009 (P =.02), and rs2307973 (P =.02). For transmission of six-marker haplotypes, the global P value was.0000016 (5 degrees of freedom), principally because of overtransmission of the most common haplotype, CAA/-/G/T/C/- (frequency 53.6%; chi (2) = 20.8; P =.0000051). This confirms our previous study and provides further support for the role of synapsin II variants in susceptibility to schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.