ArticleHuman genetics2004
Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Lynch Syndrome in Focus: A Multidisciplinary Review of Cancer Risk, Clinical Management, and Special Populations.Cancers · 2025Review
- Carrier Frequency and Incidence ofAnnals of laboratory medicine · 2025Article
- 8-Oxoguanine DNA Glycosylase 1 Upregulation as a Risk Factor for Obesity and Colorectal Cancer.International journal of molecular sciences · 2023Article
- New insights on familial colorectal cancer type X syndrome.Scientific reports · 2022Article
- Dominantly Inherited Hereditary Nonpolyposis Colorectal Cancer Not Caused by MMR Genes.Journal of clinical medicine · 2020Review
- Overexpression of Srcin1 contributes to the growth and metastasis of colorectal cancer.International journal of oncology · 2017Article
- In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA Damage.Chembiochem : a European journal of chemical biology · 2015Article
- Expression of XPG protein in the development, progression and prognosis of gastric cancer.PloS one · 2014Article
- Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients.Medical oncology (Northwood, London, England) · 2012Article
- Clinical and molecular detection of inherited colorectal cancers in northeast Italy: a first prospective study of incidence of Lynch syndrome and MUTYH-related colorectal cancer in Italy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- 8-Hydroxydeoxyguanosine: not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases.World journal of gastroenterology · 2012Review
- Frequency of the common germline MUTYH mutations p.G396D and p.Y179C in patients diagnosed with colorectal cancer in Southern Brazil.International journal of colorectal disease · 2011Article
- MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population.Journal of experimental & clinical cancer research : CR · 2009Article
- Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.Journal of experimental & clinical cancer research : CR · 2008Article
- MUTYH Associated Polyposis (MAP).Current genomics · 2008Article
- DNA repair dysfunction in gastrointestinal tract cancers.Cancer science · 2008Review
- Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population.Cancer science · 2008Article
- MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas.Virchows Archiv : an international journal of pathology · 2007Article
- Biology of SNU cell lines.Cancer research and treatment · 2005Article
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MYH, OGG1 and MTH1 are members of base excision repair (BER) families, and MYH germline mutations were recently identified in patients with multiple adenomas or familial adenomatous polyposis (FAP). A total of 20 APC-negative Korean FAP patients were analyzed for OGG1, MYH and MTH1 germline mutations. A total of 19 hereditary nonpolyposis colorectal cancer (HNPCC), 86 suspected HNPCC, and 246 sporadic colorectal cancer cases were investigated for OGG1 and MYH mutations. A total of 14 R154H OGG1 polymorphisms were identified in hereditary, sporadic colorectal cancers, and normal controls. For the case-control analysis of OGG1 R154H, a total of 625 hereditary or sporadic colorectal cancer patients and 527 normal controls were screened. R154H was a rare polymorphism associated with sporadic colorectal cancer patents (OR: 3.586, P= 0.053). R154H does not segregate with cancer phenotypes. Upon examining the possibility of recessive inheritance of R154H, we could not identify any complementary mutations in OGG1, MYH or MTH1. Samples with R154H were further screened for mutations of K-ras, beta-catenin, APC, p53, BRAF and the microsatellite instability (MSI) status. Eight somatic mutations were identified in these genes and G:C to T:A transversion mutations were not dominant in samples harboring R154H. This result raises the possibility that OGG1 R154H may function as a low/moderate-penetrance modifier for colorectal cancer development.
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