ArticlePediatric nephrology (Berlin, Germany)2004
Effects of advanced glycosylation endproducts on perlecan core protein of glomerular epithelium.
Article in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
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- Effects of concentrated growth factor and nanofat on aging skin of nude mice induced by D-galactose.Physiological research · 2021Article
- Adipose stem cells' antagonism in glycosylation of D-galactose-induced skin aging of nude mice and its skin recovery function.International journal of immunopathology and pharmacology · 2016Article
- Effects of interleukin-13 and montelukast on the expression of zonula occludens-1 in human podocytes.Yonsei medical journal · 2015Article
- Ginseng total saponin modulates the changes of α-actinin-4 in podocytes induced by diabetic conditions.Journal of ginseng research · 2014Article
- Diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes.Kidney research and clinical practice · 2014Article
- Ginseng total saponin modulates podocyte p130Cas in diabetic condition.Journal of ginseng research · 2013Article
- Perlecan and synaptophysin changes in denervated skeletal muscle.Neural regeneration research · 2012Article
- Ginseng total saponin improves podocyte hyperpermeability induced by high glucose and advanced glycosylation endproducts.Journal of Korean medical science · 2011Article
- A comparative proteomic study of nephrogenesis in intrauterine growth restriction.Pediatric nephrology (Berlin, Germany) · 2010Article
- High-glucose and advanced glycosylation end products increased podocyte permeability via PI3-K/Akt signaling.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Regulation of type IV collagen alpha chains of glomerular epithelial cells in diabetic conditions.Journal of Korean medical science · 2009Article
- Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes.Molecular and cellular biochemistry · 2007Article
- Effect of hyperglycemic condition on proteoglycan secretion in cultured human endothelial cells.European journal of nutrition · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perlecan is one of major heparan sulfate proteoglycans in the glomerular basement membrane and is reduced in the renal parenchyma of diabetic patients and animals with proteinuria. To examine the effects of glucose and advanced glycosylated end-products (AGE) on perlecan, we cultured rat glomerular epithelial cells (GEpC) on AGE- or bovine serum albumin (BSA)-coated plates under normal (NG, 5 mM) and high-glucose (HG, 30 mM) conditions and measured the change in perlecan core protein production by a sandwich ELISA and northern blot analysis. We observed significant decreases of perlecan core protein under HG conditions at 1 week incubation, specifically on the AGE-coated compared with the BSA-coated surface, by 22.2% and 4.7%, respectively. The expression of mRNA for perlecan promoter was decreased under HG conditions on AGE-coated surfaces by 19.7% at 2 days and 61.1% at 1 week. Even under NG condition, the expression of mRNA was reduced by 30% at 1 week if GEpC were grown on an AGE-coated surface. In conclusion, HG and AGE have an additive effect in reducing the production of perlecan core protein by GEpC in vitro. AGE had a greater effect than HG, implying that the inhibition of AGE formation may be more effective than short-term glucose control in the prevention of diabetic proteinuria.
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