ReviewDer Anaesthesist2004
[Propofol infusion syndrome].
Review in Der Anaesthesist, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- [Total intravenous anesthesia with propofol and remifentanil. Results of a multicenter study of 6,161 patients].Der Anaesthesist · 2005Trial
- Review
- Propofol infusion-like syndrome in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- [Characteristics of anesthesia in patients with MELAS syndrome: Case report of anesthesia in video-assisted thoracoscopy].Der Anaesthesist · 2015Article
- Propofol infusion syndrome: a retrospective analysis at a level 1 trauma center.Critical care research and practice · 2014Article
- Propofol infusion syndrome or not? A case report.Ochsner journal · 2014Article
- Propofol infusion syndrome in refractory status epilepticus.Journal of epilepsy research · 2013Article
- [Off-label use of drugs in pediatric emergencies: limitations and grey areas of drug approval].Der Anaesthesist · 2013Review
- Effect of propofol in the immature rat brain on short- and long-term neurodevelopmental outcome.PloS one · 2013Article
- Drug induced rhabdomyolysis.Current opinion in pharmacology · 2012Review
- [Dialysis for severe rhabdomyolysis 7 days after multiple trauma].Der Anaesthesist · 2012Article
- A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review.Case reports in gastroenterology · 2010Article
- Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia.Neurotoxicity research · 2009Article
- [Long-term therapy with propofol has no impact on microcirculation in medical intensive care patients].Medizinische Klinik (Munich, Germany : 1983) · 2009Article
- Propofol infusion syndrome: an overview of a perplexing disease.Drug safety · 2008Review
- [Propofol infusion syndrome].Der Anaesthesist · 2006Article
- [Refractory status epilepticus: diagnosis, therapy, course, and prognosis].Der Nervenarzt · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate acidosis and muscular necrosis. It has been postulated that propofol might act as a trigger substrate in the presence of priming factors. Severe diseases in which the patient has been exposed to high catecholamine and cortisol levels have been identified as trigger substrates. Once the development of propofol infusion syndrome is suspected, propofol infusion has to be stopped immediately and specific therapeutic measures initiated, including cardiocirculatory stabilization and correction of metabolic acidosis. To increase elimination of propofol and its potential toxic metabolites, hemodialysis or hemofiltration are recommended. Due to its possible fatal side effects, the use of propofol for long-term sedation in critically ill patients should be reconsidered. In cases of unexplained lactate acidosis occurring during continuous propofol infusion, propofol infusion syndrome must be taken into consideration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.