Evidence map›Paper›PMID 15448639›Full record

ArticleEMBO reports2004

SNM-dependent recombinational repair of oxidatively induced DNA damage in Arabidopsis thaliana.

Jean Molinier, Marie-Eve Stamm, Barbara Hohn

Abstract read
In one paragraph

Article in EMBO reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. De Novo Assembly of a NewThe Plant cell · 2017
    Article
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  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jean MolinierFriedrich Miescher-Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. jean.molinier@fmi.ch
Marie-Eve Stamm
Barbara Hohn

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two different roles for SNM (sensitive to nitrogen mustard) proteins have already been described: the SNM1/PSO2-related proteins are involved in the repair of the interstrand crosslink (ICL) and the ARTEMIS proteins are involved in the V(D)J recombination process. Our study shows that an Arabidopsis SNM protein, although structurally closer to the SNM1/PSO2 members, shares some properties with ARTEMIS but also has novel characteristics. Arabidopsis plants defective for the expression of AtSNM1 did not show hypersensitivity to the ICL-forming agents but to the chemotherapeutic agent bleomycin and to H(2)O(2). AtSNM1 mutant plants are delayed in the repair of oxidative damage and did not show enhancement of the frequency of somatic homologous recombination on exposure to H(2)O(2) and to the bacterial elicitor flagellin, both inducing oxidative stress, as observed in the control plants. Therefore, our results suggest the existence, in plants, of a novel SNM-dependent recombinational repair process of oxidatively induced DNA damage.

Indexed as

ArabidopsisArabidopsis ProteinsDNA-Binding ProteinsDNA DamageDNA RepairEndodeoxyribonucleasesNuclear ProteinsReactive Oxygen SpeciesRecombination, GeneticSaccharomyces cerevisiae ProteinsArabidopsis ProteinsDNA-Binding ProteinsEndodeoxyribonucleasesNuclear ProteinsPSO2 protein, S cerevisiaeReactive Oxygen SpeciesSaccharomyces cerevisiae ProteinsSNM1 protein, Arabidopsis

Identifiers

PMID15448639
PMCPMC1299156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.