ReviewIndian journal of pediatrics2004
Hyponatremia in hospitalized critically ill children: current concepts.
Review in Indian journal of pediatrics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Successful Management of Cerebral Salt-Wasting Syndrome in a Child With Epileptic Encephalopathy: A Case Report.Clinical case reports · 2025Article
- Article
- Postoperative hyponatremia in neonates with esophageal atresia and tracheoesophageal fistula receiving restricted hypotonic fluids.Annals of pediatric surgery · 2022Article
- A Prospective Cohort Study on Serum Sodium and Clinical Outcome in Pediatric Nontraumatic Coma.Indian journal of pediatrics · 2021Article
- Distinguishing Multisystem Inflammatory Syndrome in Children From Kawasaki Disease and Benign Inflammatory Illnesses in the SARS-CoV-2 Pandemic.Pediatric emergency care · 2020Article
- Hospital-acquired Hyponatremia in Pediatric Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- Maintenance intravenous fluids for children with central nervous system infections.Indian journal of pediatrics · 2015Article
- Impact of perioperative hyponatremia in children: A narrative review.World journal of critical care medicine · 2014Review
- Inflammation and hyponatremia: an underrecognized condition?Korean journal of pediatrics · 2013Review
- After the FEAST--fluid resuscitation in pediatric sepsis.Indian journal of pediatrics · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia (serum sodium to < 136 mEq/l) is the most common electrolyte abnormality in critically ill children. It could result from a deficit of sodium, or surplus of water. Impaired water excretion, 'inappropriate' release of vasopressin, use of hypotonic fluids, redistribution of sodium and water, sick cell syndrome, several drugs and primary illness all may contribute to hyponatremia. Acute hyponatremia, defined as a fall in serum sodium to ~ 120 mEq/l within 48 hours may result in acute cerebral edema and brain stem herniation particularly in children. However, there is paucity of data on hyponatremia in hospitalized critically ill patients. Studies addressing incidence, cause and outcome of hyponatremia in critically ill patients are needed to plan rational fluid therapy protocols, and resolve the current debate, which calls for abandonment of N/5 saline in 5% dextrose solution as maintenance intravenous fluid in favour of normal saline to prevent hyponatremia. At present it is not fully correct to assume that isotonic maintenance fluids would be superior to current maintenance fluids. Reducing the volume of maintenance fluid to about 75% of normal maintenance volume may be more appropriate way to prevent hyponatremia in view of water retaining effect of high ADH and reduced renal free water clearance in critically ill children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.