ArticleBrain pathology (Zurich, Switzerland)2004
Genetic and expression profiles of cerebellar liponeurocytomas.
Article in Brain pathology (Zurich, Switzerland), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 81 citations in OpenAlex.
- Stereotactic radiosurgery for progression of cerebellar liponeurocytoma after resection: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Cerebellar liponeurocytoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Epigenetic Regulation in Primary CNS Tumors: An Opportunity to Bridge Old and New WHO Classifications.Cancers · 2023Review
- Glioneuronal and Neuronal Tumors of the Central Nervous System.Advances in experimental medicine and biology · 2023Article
- Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of seven cases and a pooled analysis of individual patient data.Neurosurgical review · 2022Article
- A case of adult cerebellar liponeurocytoma with atypical radiological features and long survival with literature review.Radiology case reports · 2022Article
- Cerebellar Liponeurocytoma Mimicking Medulloblastoma: Case Report of a Childhood and Literature Review.Frontiers in oncology · 2021Article
- Uncommon low-grade brain tumors.Neuro-oncology · 2019Review
- Cerebellar liponeurocytoma - a rare entity: a case report.Journal of medical case reports · 2018Article
- Cerebellar Liponeurocytoma: Relevant Clinical Cytogenetic Findings.Journal of pathology and translational medicine · 2017Article
- Understanding cerebellar liponeurocytomas: case report and literature review.Case reports in neurological medicine · 2014Article
- Papillary glioneuronal tumor--a rare entity: report of four cases and brief review of literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
- Cerebellar liponeurocytoma with an unusually aggressive histopathology : case report and review of the literature.Journal of Korean Neurosurgical Society · 2012Article
- FABP4 is a candidate marker of cerebellar liponeurocytomas.Journal of neuro-oncology · 2012Article
- Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature.Journal of neuro-oncology · 2011Review
- A recurrent cerebellar lesion in a young boy.Brain pathology (Zurich, Switzerland) · 2008Article
- Cerebellar Liponeurocytoma: A Rare Fatty Tumor and its Literature Review.Journal of neurosciences in rural practiceArticle
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Authors and funding
28 authors at 9 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar liponeurocytoma, a rare, newly identified CNS neoplasm of adults, is characterized by advanced neuronal/neurocytic and focal lipomatous differentiation, low proliferative potential and a favorable clinical prognosis. Despite the different age distribution and benign biological behavior, the cerebellar liponeurocytoma shares several features with the cerebellar medulloblastoma, which may include an origin from the periventricular matrix of the fourth ventricle or the external granular layer of the cerebellum. To establish the genetic profile of cerebellar liponeurocytomas, we have formed an international consortium and collected tumor samples from 20 patients. DNA sequencing revealed TP53 missense mutations in 4 (20%) of 20 cerebellar liponeurocytomas, a frequency higher than in medulloblastomas. There was no case with PTCH, APC, or beta-catenin mutations, each of which may be present in subsets of medulloblastomas. Isochromosome 17q, a genetic hallmark of classic medulloblastomas, was not observed in any of the cases investigated by FISH analysis. cDNA array analyses were carried out on 4 cerebellar liponeurocytomas, 4 central neurocytomas, and 4 classic medulloblastomas. Cluster analysis of the cDNA expression data of 1176 genes grouped cerebellar liponeurocytomas close to central neurocytomas, but distinct from medulloblastomas. These results suggest cerebellar liponeurocytoma as a distinct tumor entity that is genetically different from medulloblastoma. Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different.
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