ArticleClinical and experimental immunology1992
Immune complex glomerulonephritis in experimental kala-azar. II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Crescentic glomerulonephritis associated with myelodysplatic syndrome and visceral leishmaniasis.Journal of nephrology · 2025Article
- Continuous hypergammaglobulinemia and proteinuria after the recovery of the visceral Leishmaniasis: a case report.BMC infectious diseases · 2021Article
- Identification of Leishmania donovani antigen in circulating immune complexes of visceral leishmaniasis subjects for diagnosis.PloS one · 2017Article
- Renal leishmaniasis as unusual cause of nephrotic syndrome in an HIV patient.Journal of the American Society of Nephrology : JASN · 2012Article
- Immunobiology of visceral leishmaniasis.Frontiers in immunology · 2012Article
- Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus Syrian hamster model.Veterinary research · 2011Review
- T cells, adhesion molecules and modulation of apoptosis in visceral leishmaniasis glomerulonephritis.BMC infectious diseases · 2010Article
- The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers.Clinical and experimental immunology · 2007Article
- Visceral leishmaniasis resembling systemic lupus erythematosus.Clinical rheumatology · 2003Article
- Glomerulopathy associated with parasitic infections.Clinical microbiology reviews · 2000Review
- Antigenicity of the Leishmania infantum histones H2B and H4 during canine viscerocutaneous leishmaniasis.Clinical and experimental immunology · 1999Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous report analysing kidney sections by immunofluorescence we showed that hamsters infected with L. donovani develop a glomerulonephritis (GN) associated with deposition of hamster immunoglobulins and parasite antigens in the glomeruli. In this study we characterize these immune components eluted from the kidneys. The eluted immunoglobulins showed specificity for L. donovani antigens and hamster immunoglobulins (rheumatoid factor-like activity). The four isotypes IgG1, IgG2, IgA and IgM were detected. Several L. donovani antigens were detected in the renal eluates by Western blot and immunoprecipitation using 125I-labelled eluates. Proteins with mol. wt of 134, 82, 52, 31, and 26 kD were detected by Western blot and proteins with 134, 110, 93, 89 and 48 kD were detected by immunoprecipitation. With the exception of the 134 kD protein which was recognized by both rabbit anti-promastigote and rabbit anti-amastigote sera all the others were recognized only by the anti-amastigote serum. The 134 kD protein was the only one isolated from the kidneys of infected hamster immunocomplexed with IgG and was the only one detected in a promastigote lysate using IgG from L. donovani-infected hamsters.
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