ArticleMammalian genome : official journal of the International Mammalian Genome Society1992
A second ferritin L subunit is encoded by an intronless gene in the mouse.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- HMGA1-pseudogenes and cancer.Oncotarget · 2016Review
- Oncogenic activation of MAP kinase by BRAF pseudogene in thyroid tumors.Neoplasia (New York, N.Y.) · 2009Article
- Article
- Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.Molecular and cellular biology · 1999Article
- Article
- Genetic mapping of the mouse ferritin light chain gene and 11 pseudogenes on 11 mouse chromosomes.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Reverse transcriptase: mediator of genomic plasticity.Virus genes · 1995Review
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5 authors.
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Abstract
Multiple homologous sequences for the ferritin L subunit are present in mammalian genomes, but so far, only one expressed gene has been described. Here we report the isolation of a cDNA from a mouse bone marrow library, corresponding to an isoform of the mouse ferritin L subunit. This new subunit, that we named Lg, differs from the L subunit of ten amino acids. Specific amplification of mouse genomic DNA using the polymerase chain reaction (PCR) confirmed the presence of this Lg sequence in the mouse genome but also suggested that it must be encoded by an intronless gene. Using a series of different Lg-specific oligonucleotides as probes, we subsequently isolated a genomic clone containing an uninterrupted sequence, identical to the Lg cDNA. This Lg gene lacks introns and does not contain the 28 base pairs (bp) conserved motif usually present at the 5' end of most ferritin mRNAs, which confers translational regulation by iron. When transiently transfected into K562 cells, this Lg genomic clone is actively transcribed, suggesting that, although it possesses the characteristics of a processed pseudogene, it is likely to correspond to the gene encoding this new ferritin subunit.
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