ArticleMammalian genome : official journal of the International Mammalian Genome Society1992
Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Murine albino-deletion complex: high-resolution microsatellite map and genetically anchored YAC framework map.Genetics · 1997Article
- Article
- Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.Genetics · 1995Article
- A high-resolution map of the brown (b, Tyrp1) deletion complex of mouse chromosome 4.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Molecular genetics of the brown (b)-locus region of mouse chromosome 4. II. Complementation analyses of lethal brown deletions.Genetics · 1994Article
- A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Deletion mapping of the chocolate (cht) locus within the Fes-Hbb region of mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complementation analyses of radiation-induced deletion mutations involving the albino (c) locus in Chromosome (Chr) 7 of the mouse have identified several loci, in addition to c, that have important roles in development. The "mesoderm-deficient" (msd) and "hepatocyte-specific developmental regulation-1" (hsdr-1) loci, which are proximal and tightly linked to c, are important in the formation of mesoderm and in the regulation of liver- and kidney-specific induction of various enzymes and proteins, respectively. Cloning deletion-breakpoint-fusion fragments caused by lethal albino deletions that genetically define the extents of the msd and hsdr-1 loci is one way of generating molecular probes for studying the gene(s) involved in these phenotypes. The distal breakpoints of five such deletions were positioned on a long-range (PFGE) map of approximately 1.7 Mb of wild-type DNA surrounding the c, D7Was12, and Emv-23 loci. In addition, the distal breakpoints of two viable albino deletions, which remove part of the tyrosinase gene and extend distally, were localized in the vicinity of the lethal deletion breakpoints. Therefore, the viable deletions can be exploited to generate additional DNA probes that should facilitate the isolation of breakpoint clones from chromosomes carrying lethal deletions defining hsdr-1 and msd.
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