ArticleProceedings of the National Academy of Sciences of the United States of America1992
Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 112 citations in OpenAlex.
- Blocking Dirofilaria immitis transmission by treatment of heartworm microfilaremic dogs with doxycycline.Parasites & vectors · 2026Article
- Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response.Genetics · 2023Article
- Article
- Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle WithFrontiers in cellular and infection microbiology · 2022Review
- A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.Journal of immunology research · 2021Article
- Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi.BMC genomics · 2012Article
- Insect chitinase and chitinase-like proteins.Cellular and molecular life sciences : CMLS · 2010Review
- Use of microarray hybridization to identify Brugia genes involved in mosquito infectivity.Parasitology research · 2009Article
- Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi.Molecular and biochemical parasitology · 2008Article
- Essential role of chitinase in the development of the filarial nematode Acanthocheilonema viteae.Infection and immunity · 2008Article
- Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products.PLoS neglected tropical diseases · 2008Article
- Molecular characterization, expression, and in vivo analysis of LmexCht1: the chitinase of the human pathogen, Leishmania mexicana.The Journal of biological chemistry · 2005Article
- Human immune responses to infective stage larval-specific chitinase of filarial parasite, Onchocerca volvulus, Ov-CHI-1.Filaria journal · 2003Article
- Insect resistance of transgenic tobacco expressing an insect chitinase gene.Transgenic research · 1998Article
- Characterization of chitinase C from a marine bacterium, Alteromonas sp. strain O-7, and its corresponding gene and domain structure.Applied and environmental microbiology · 1998Article
- Antibody-mediated inhibition of the growth of larvae from an insect causing cutaneous myiasis in a mammalian host.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Secretion of an enzymatically active Trichoderma harzianum endochitinase by Saccharomyces cerevisiae.Current genetics · 1996Article
- Comparison of the patterns of codon usage and bias between Brugia, Echinococcus, Onchocerca and Schistosoma species.Parasitology research · 1995Article
- Molecular characterization of a novel tobacco pathogenesis-related (PR) protein: a new plant chitinase/lysozyme.Molecular & general genetics : MGG · 1994Article
- Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti.Infection and immunity · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. The monoclonal antibody MF1, which mediates clearance of peripheral microfilaremia in a gerbil infection model, recognizes two stage-specific proteins, p70 and p75, in B. malayi microfilariae. cDNA coding for the MF1 antigen was sequenced, and the predicted protein sequence shows significant similarities to chitinases from bacteria and yeast. When microfilarial extracts and purified preparations of the MF1 antigen were tested for chitinase activity, strong bands of chitin-degrading activity comigrated in SDS/PAGE with p70 and p75 and showed a reduction-dependent mobility shift characteristic of the MF1 antigen. Thus, the MF1 antigen is microfilarial chitinase, which may function to degrade chitin-containing structures in the microfilaria or in its mosquito vector during parasite development and transmission.
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Registered trials
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