ArticleThe Journal of clinical investigation1992
Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation. The Collaborative Vaccine Study Group.The Journal of clinical investigation · 1993Trial
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- Antigen nature and complexity influence human antibody light chain usage and specificity.Vaccine · 2016Article
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- Molecular analysis of monoclonal antibodies to group variant capsular polysaccharide of Neisseria meningitidis: recurrent heavy chains and alternative light chain partners.Molecular immunology · 2005Article
- Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles.Infection and immunity · 2004Article
- Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin Loci.Infection and immunity · 2002Article
- Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.Journal of virology · 2000Article
- Production of protective human antipneumococcal antibodies by transgenic mice with human immunoglobulin loci.Infection and immunity · 2000Article
- Structural requirements of the major protective antibody to Haemophilus influenzae type b.Infection and immunity · 1999Article
- Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues.Infection and immunity · 1999Article
- Differential use of immunoglobulin light chain genes and B lymphocyte expansion at sites of disease in rheumatoid arthritis (RA) compared with circulating B lymphocytes.Clinical and experimental immunology · 1998Article
- Heterogeneity of antibodies reactive with the dominant antigen of Actinobacillus actinomycetemcomitans.Infection and immunity · 1997Article
- VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.Journal of immunology (Baltimore, Md. : 1950) · 1997Article
- A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease.The Journal of clinical investigation · 1996Article
- Molecular and idiotypic analysis of antibodies to Cryptococcus neoformans glucuronoxylomannan.Infection and immunity · 1994Article
- Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.Infection and immunity · 1994Article
- Molecular analysis of the human immunoglobulin V lambda II gene family.The Journal of clinical investigation · 1994Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The immune repertoire to Haemophilus influenzae type b capsular polysaccharide (Hib PS) appears to be dominated by certain light chain variable region genes (IgVL). In order to examine the molecular basis underlying light chain bias, IgVL genes have been cloned from a panel of heterohybridomas secreting human anti-Hib PS (antibody) (anti-Hib PS Ab). One hybridoma, representative of the predominant serum clonotype of anti-Hib PS Ab in older children and adults following immunization or Hib infection, uses a V kappa II segment identical to the germline gene A2, and a JK3 segment. A second kappa hybridoma uses a member of the V kappa I family and a JK4 segment. Four lambda antibodies, all cross-reactive with the structurally related antigen Escherichia coli K100 PS, use V lambda VII segments which are 96-98% homologous to one another, and may originate from a single germline gene. Two additional lambda antibodies, not K100-cross-reactive, are encoded by members of the V lambda II family. All lambda antibodies use highly homologous J lambda 2 or J lambda 3 segments. The VJ joints of all lambda antibodies and the V kappa II-encoded antibody are notable for the presence of an arginine codon, suggesting an important role in antigen binding. Although more complex than heavy chain variable region gene usage, a significant portion of serum anti-Hib PS Ab is likely to be encoded by a limited number of V kappa and V lambda segments and VJ combinations, which may be selectively expressed during development, or following antigen exposure.
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