ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 region.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Genome-wide association analyses reveal significant loci and strong candidate genes for growth and fatness traits in two pig populations.Genetics, selection, evolution : GSE · 2015Article
- Proteomic analysis of liver in miniature pigs according to developmental stages using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry.Laboratory animal research · 2013Article
- A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs.Molecular biology reports · 2010Article
- Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene.Molecular biology reports · 2009Article
- A robust linkage map of the porcine autosomes based on gene-associated SNPs.BMC genomics · 2009Article
- A new 4016-marker radiation hybrid map for porcine-human genome analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Refined localization of the FAT1 quantitative trait locus on pig chromosome 4 by marker-assisted backcrossing.BMC genetics · 2006Article
- On growth, fatness, and form: a further look at porcine chromosome 4 in an Iberian x Landrace cross.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
The first quantitative trait locus (QTL) in pigs, FAT1, was found on Chromosome 4 (SSC4) using a Wild Boar intercross. Further mapping has refined the FAT1 QTL to a region with conserved synteny to both human Chromosomes 1 and 8. To both improve the comparative map of the entire SSC4 and to define the specific human chromosome region with conserved synteny to FAT1, we have now mapped 103 loci to pig Chromosome 4 using a combination of radiation hybrid and linkage mapping. The physical data and linkage analysis results are in very good agreement. Comparative analysis revealed that gene order is very well conserved across SSC4 compared to both HSA1 and HSA8. The breakpoint in conserved synteny was refined to an area of about 23 cR on the q arm of SSC4 corresponding to a genetic distance of less than 0.5 cM. Localizations of the centromeres do not seem to have been conserved between the two species. No remnants of the HSA1 centromere were detected on the corresponding region on SSC4 and traces from the centromeric region of SSC4 cannot clearly be revealed on the homologous region on HSA8. This refined SSC4 map and the comparative analysis will be a great aid in the search for the genes underlying the FAT1 locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.