ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
Loci affecting male fertility in hybrids between Mus macedonicus and C57BL/6.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary.Molecular biology and evolution · 2021Article
- Article
- X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids.PLoS genetics · 2014Article
- Independent specialization of the human and mouse X chromosomes for the male germ line.Nature genetics · 2013Article
- Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Extraordinary sequence divergence at Tsga8, an X-linked gene involved in mouse spermiogenesis.Molecular biology and evolution · 2011Article
- Reproductive isolation in hybrid mice due to spermatogenesis defects at three meiotic stages.Genetics · 2010Article
- Genetic dissection of testis weight in a mouse strain having an extremely large testis: major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2008Article
- Centimorgan-range one-step mapping of fertility traits using interspecific recombinant congenic mice.Genetics · 2007Article
- Signatures of reproductive isolation in patterns of single nucleotide diversity across inbred strains of mice.Genetics · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Male F1 hybrids between inbred strains and Mus macedonicus have very small testes and are sterile. Cytological analysis of testes shows very few meioses. To determine the genetic basis for this sterility, (C57BL/6J x Mus macedonics) F1 females were mated to males from C57BL/10J. In about half the male progeny no meiosis I was observed. About half of the animals that progressed through meiosis I showed other indications of low fertility and the balance appeared fertile. QTL analysis of the progeny suggested that loci on proximal Chrs 17 and X were involved in the sterility and a locus on Chr X in variation of body weight. There is also evidence that X//Y dissociation of the pseudo-autosomal region occurs. The QTLs on Chrs X and 17 together account for about 37% of the variance for testis weight. Congenic lines B.MAC-X(1-38), and B.MAC-17(1-23) have been constructed using a modified speed congenic approach. Testis tubules from B.MAC-X(1-38) are narrow and vacuolated. They contain only Sertoli cells and mitotically dividing spermatogonia. Very occasionally a meiotic metaphase can be observed, but no sperm are produced. Homozygous males from B.MAC-17(1-23) are sterile, producing sperm heads but no complete sperm.
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