ArticleRNA (New York, N.Y.)2004
Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Article
- Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay.The Journal of biological chemistry · 2022Review
- Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- UPF1-Mediated RNA Decay-Danse Macabre in a Cloud.Biomolecules · 2020Review
- Role of the uS9/yS16 C-terminal tail in translation initiation and elongation in Saccharomyces cerevisiae.Nucleic acids research · 2019Article
- Decoding the Function of Expansion Segments in Ribosomes.Molecular cell · 2018Article
- Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins.Journal of cell science · 2017Article
- Review
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Chemical-Induced Read-Through at Premature Termination Codons Determined by a Rapid Dual-Fluorescence System Based on S. cerevisiae.PloS one · 2016Article
- Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes.RNA (New York, N.Y.) · 2011Article
- Translational errors: from yeast to new therapeutic targets.FEMS yeast research · 2010Review
- A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding.Nucleic acids research · 2010Article
- Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors.RNA (New York, N.Y.) · 2010Article
- Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins.Nucleic acids research · 2010Article
- Role of premature stop codons in bacterial evolution.Journal of bacteriology · 2008Article
- Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation.RNA (New York, N.Y.) · 2008Article
- Structure/function analysis of yeast ribosomal protein L2.Nucleic acids research · 2008Article
- Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.The EMBO journal · 2008Article
- rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The Upf proteins are essential for nonsense-mediated mRNA decay (NMD). They have also been implicated in the modulation of translational fidelity at viral frameshift signals and premature termination codons. How these factors function in both mRNA turnover and translational control remains unclear. In this study, mono- and bicistronic reporter systems were used in the yeast Saccharomyces cerevisae to differentiate between effects at the levels of mRNA turnover and those at the level of translation. We confirm that upfDelta mutants do not affect programmed frameshifting, and show that this is also true for mutant forms of eIF1/Sui1p. Further, bicistronic reporters did not detect defects in translational readthrough due to deletion of the UPF genes, suggesting that their function in termination is not as general a phenomenon as was previously believed. The demonstration that upf sui1 double mutants are synthetically lethal demonstrates an important functional interaction between the NMD and translation initiation pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.