ArticleRNA (New York, N.Y.)2004
Nontemplated nucleotide addition prior to polyadenylation: a comparison of Arabidopsis cDNA and genomic sequences.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- The identity of the discriminator base has an impact on CCA addition.Nucleic acids research · 2015Article
- SCOPE++: sequence classification of homoPolymer emissions.Genomics · 2014Article
- Motif types, motif locations and base composition patterns around the RNA polyadenylation site in microorganisms, plants and animals.BMC evolutionary biology · 2014Article
- Bioinformatics analysis of alternative polyadenylation in green alga Chlamydomonas reinhardtii using transcriptome sequences from three different sequencing platforms.G3 (Bethesda, Md.) · 2014Article
- Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues.Molecular plant · 2013Review
- Article
- Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation.Nature structural & molecular biology · 2012Article
- tRNA nucleotidyltransferases: ancient catalysts with an unusual mechanism of polymerization.Cellular and molecular life sciences : CMLS · 2010Review
- A polyadenylation factor subunit implicated in regulating oxidative signaling in Arabidopsis thaliana.PloS one · 2008Article
- Article
- ConiferEST: an integrated bioinformatics system for data reprocessing and mining of conifer expressed sequence tags (ESTs).BMC genomics · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comparison of Arabidopsis DNA sequences revealed that the final nucleotides at the 3' end of approximately half of the Arabidopsis mRNAs, immediately upstream of the poly(A) tail, differ from the corresponding genomic sequences. This suggests that extra nucleotides were added to these mRNAs at their 3' termini prior to polyadenylation. Among the mRNAs containing additional nucleotides, approximately 65% had a single additional nucleotide, with the nucleotide C added most often. This nontemplated addition before the addition of the poly(A) sequence could be a major contributing factor to the often observed heterogeneity in transcription products. These findings should be helpful in the elucidation of the mechanisms of mRNA 3'-end processing.
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