ArticleThe Journal of physiology2004
Regulation of transmitter release by synapsin II in mouse motor terminals.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy.Nature communications · 2025Article
- Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation.Cellular & molecular biology letters · 2023Article
- Pre-clinical symptoms of SBMA may not be androgen-dependent: implications from two SBMA mouse models.Human molecular genetics · 2018Article
- Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction.Journal of visualized experiments : JoVE · 2017Article
- Electrophysiological analysis of synaptic transmission in Drosophila.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Synapsin II Regulation of GABAergic Synaptic Transmission Is Dependent on Interneuron Subtype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum.Molecular neurobiology · 2015Article
- Functions of synapsins in corticothalamic facilitation: important roles of synapsin I.The Journal of physiology · 2015Article
- Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.Neuropharmacology · 2015Article
- ATP binding to synaspsin IIa regulates usage and clustering of vesicles in terminals of hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth.Human molecular genetics · 2014Article
- Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Alpha-synuclein loss in spinal muscular atrophy.Journal of molecular neuroscience : MN · 2011Article
- Diffuse and specific tectopulvinar terminals in the tree shrew: synapses, synapsins, and synaptic potentials.PloS one · 2011Article
- Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons.Neuroscience · 2010Article
- Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.Molecular and cellular neurosciences · 2010Article
- The role of synapsins in neuronal development.Cellular and molecular life sciences : CMLS · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
We investigated quantal release and ultrastructure in the neuromuscular junctions of synapsin II knockout (Syn II KO) mice. Synaptic responses were recorded focally from the diaphragm synapses during electrical stimulation of the phrenic nerve. We found that synapsin II affects transmitter release in a Ca(2+)-dependent manner. At reduced extracellular Ca(2+) (0.5 mM), Syn II KO mice demonstrated a significant increase in evoked and spontaneous quantal release, while at the physiological Ca(2+) concentration (2 mM), quantal release in Syn II KO synapses was unaffected. Protein kinase inhibitor H7 (100 microM) suppressed quantal release significantly stronger in Syn II KO synapses than in wild type (WT), indicating that Syn II KO synapses may compensate for the lack of synapsin II via a phosphorylation-dependent pathway. Electron microscopy analysis demonstrated that the lack of synapsin II results in an approximately 40% decrease in the density of synaptic vesicles in the reserve pool, while the number of vesicles docked to the presynaptic membrane remained unchanged. Synaptic depression in Syn II KO synapses was slightly increased, which is consistent with the depleted vesicle store in these synapses. At reduced Ca(2+) frequency facilitation of synchronous release was significantly increased in Syn II KO, while facilitation of asynchronous release was unaffected. Thus, at the reduced Ca(2+) concentration, synapsin II suppressed transmitter release and facilitation. These results demonstrate that synapsin II can regulate vesicle clustering, transmitter release, and facilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.