ArticleThe Journal of physiology2004
Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 91 citations in OpenAlex.
- Effects of bicarbonate ingestion and high intensity exercise on lactate and H(+)-ion distribution in different blood compartments.European journal of applied physiology · 2011Trial
- OGG1 increases exercise endurance via elevated skeletal muscle FGF21.The Journal of biological chemistry · 2026Article
- The universal role of adaptive transcription in health and disease.The FEBS journal · 2025Review
- Acute whole-body vibration as a recovery strategy did not alter the content of gluteus medius monocarboxylate-transporters, lactatemia, and acidosis induced by intense exercise in horses.Frontiers in veterinary science · 2025Article
- Twice-a-day exercise increases acute MCT1 gene expression in skeletal muscle but does not change the lactate curve after 3 weeks of training in adult men.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High-Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2.Oxidative medicine and cellular longevity · 2025Article
- Exogenous Lactate Treatment Immediately after Exercise Promotes Glycogen Recovery in Type-II Muscle in Mice.Nutrients · 2024Article
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- Critical Velocity, Maximal Lactate Steady State, and Muscle MCT1 and MCT4 after Exhaustive Running in Mice.International journal of molecular sciences · 2023Article
- The effect of pre-exercise alkalosis on lactate/pH regulation and mitochondrial respiration following sprint-interval exercise in humans.Frontiers in physiology · 2023Article
- Physiological and skeletal muscle responses to high-intensity interval exercise in Thoroughbred horses.Frontiers in veterinary science · 2023Article
- Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice.Physiological reports · 2022Article
- Impact of body fat, body water content, and skeletal muscle mass index on peak salivary lactate levels after squat jump exercise in healthy non-athlete adult males.BMC sports science, medicine & rehabilitation · 2022Article
- Effect of acute swimming exercise at different intensities but equal total load over metabolic and molecular responses in swimming rats.Journal of muscle research and cell motility · 2022Article
- Lactate modulates cardiac gene expression in mice during acute physical exercise.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- The Effect of a 2-Week Red Ginseng Supplementation on Food Efficiency and Energy Metabolism in Mice.Nutrients · 2020Article
- Effects of sildenafil citrate on peripheral fatigue and exercise performance after exhaustive swimming exercise in rats.Journal of exercise rehabilitation · 2019Article
- Blood lactate and rectal temperature can predict exit velocity of beef feedlot steers.Translational animal science · 2019Article
- Lactate metabolism: historical context, prior misinterpretations, and current understanding.European journal of applied physiology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effect of a single exercise session on the protein and mRNA expression of the monocarboxylate transporters MCT1 and MCT4 in rat soleus (SOL), and red (RG) and white gastrocnemius (WG) muscles. Muscle samples were obtained at rest before 2 h of treadmill exercise (21 m min(-1), 15% grade) and immediately after exercise, as well as 5, 10 and 24 h after exercise. During the 2 h exercise bout, MCT1 proteins in RG (+60%) and WG (+56%) were increased (P < 0.05). MCT1 protein was further increased thereafter, with peak increments occurring 10 h after exercise in RG (+157%), WG (+193%) and SOL (+179%) (P < 0.05). Twenty-four hours after exercise, MCT1 protein was still up-regulated in WG (+100%) and SOL (+55%) (P < 0.05), but not in RG. MCT1 mRNA was up-regulated during exercise in RG (+53%) and WG (+98%) and remained elevated until 24 h post-exercise in RG (P < 0.05), but in WG, MCT1 mRNA decreased transiently to pre-exercise levels at 5 and 10 h after exercise, before increasing again at 24 h (+150%) (P < 0.05). MCT4 protein and mRNA were not increased in WG muscle during and after exercise (P > 0.05). In contrast, during exercise, in RG (+41%) and SOL (+98%) MCT4 protein was increased (P < 0.05). Peak increases in MCT4 protein were observed 10 h after exercise in RG (+131%) and SOL (+323%) (P < 0.05). MCT4 protein was still up-regulated 24 h after exercise (RG: +106%; SOL +225%) (P < 0.05). MCT4 mRNA in RG was not increased until 10 (+132%) and 24 h after exercise (+55%) (P < 0.05). These studies have shown that MCT1 and 4 proteins are transiently up-regulated by a single bout of exercise, involving post-transcriptional and transcriptional mechanisms. Thus, MCT1 and MCT4 belong to a class of selected metabolic genes that are very rapidly up-regulated with an exercise stimulus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.