ArticleAntimicrobial agents and chemotherapy2004
Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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106 citing papers in PubMed, 240 citations in OpenAlex.
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- Computational identification of novel natural inhibitors against triple mutant DNA gyrase A in fluoroquinolone-resistantBiochemistry and biophysics reports · 2025Article
- Unraveling the treasure trove of phytochemicals in mitigating the Salmonella enterica infection.Folia microbiologica · 2025Review
- Clonal Spread and Genetic Mechanisms Underpinning Ciprofloxacin Resistance inFoods (Basel, Switzerland) · 2025Article
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- Distribution and genetic characterization of fluoroquinolone resistance geneMicrobiology spectrum · 2024Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica isolates (n = 182) were examined for mutations in the quinolone resistance-determining region of gyrA, gyrB, parC, and parE. The frequency, location, and type of GyrA substitution varied with the serovar. Mutations were found in parC that encoded Thr57-Ser, Thr66-Ile, and Ser80-Arg substitutions. Mutations in the gyrB quinolone resistance-determining region were located at codon Tyr420-Cys or Arg437-Leu. Novel mutations were also found in parE encoding Glu453-Gly, His461-Tyr, Ala498-Thr, Val512-Gly, and Ser518-Cys. Although it is counterintuitive, isolates with a mutation in both gyrA and parC were more susceptible to ciprofloxacin than were isolates with a mutation in gyrA alone.
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