ArticleAntimicrobial agents and chemotherapy2004
Correlation between in vitro susceptibility of Scedosporium apiospermum to voriconazole and in vivo outcome of scedosporiosis in guinea pigs.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Diagnosis of pulmonary Scedosporium apiospermum infection from bronchoalveolar lavage fluid by metagenomic next-generation sequencing in an immunocompetent female patient with normal lung structure: a case report and literature review.BMC infectious diseases · 2024Review
- RecurrentJournal of fungi (Basel, Switzerland) · 2023Review
- Pharmacodynamics of Voriconazole for Invasive Pulmonary Scedosporiosis.Antimicrobial agents and chemotherapy · 2018Article
- Animal Models of Aspergillosis.Comparative medicine · 2018Review
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature.Medical mycology case reports · 2016Article
- Mycetoma medical therapy.PLoS neglected tropical diseases · 2014Review
- Experimental murine scedosporiosis: histopathology and azole treatment.Antimicrobial agents and chemotherapy · 2010Article
- Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients.Antimicrobial agents and chemotherapy · 2008Article
- Infections caused by Scedosporium spp.Clinical microbiology reviews · 2008Review
- Animal models: an important tool in mycology.Medical mycology · 2007Review
- Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.Antimicrobial agents and chemotherapy · 2006Article
- Voriconazole in the management of nosocomial invasive fungal infections.Therapeutics and clinical risk management · 2006Article
- In vitro synergistic interaction between amphotericin B and micafungin against Scedosporium spp.Antimicrobial agents and chemotherapy · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Scedosporium apiospermum in immunodepressed guinea pigs. Animals were infected with two strains; one required a VRC MIC of 0.5 to 1 microg/ml, common for this fungus, and the other required a high MIC (8 microg/ml), unusual in this species. VRC prolonged survival and reduced fungal load in kidney and brain tissues of the animals infected with the first strain but was unable to prolong survival or to reduce fungal load in brain tissue for the latter strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.