ArticleAntimicrobial agents and chemotherapy2004
Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 175 citations in OpenAlex.
- Influence of Chlamydia suis on reproductive outcome in farms with and without tetracycline treatment of sows.Veterinary research · 2026Article
- A Nationwide Investigation on the Distribution and Antimicrobial Susceptibility Profiling ofInfection & chemotherapy · 2026Article
- Anti-International journal of molecular sciences · 2026Review
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- Chlamydiosis in Animals.Animals : an open access journal from MDPI · 2024Review
- Suspected Cases of Chlamydia-Induced Fertility Problems in Sows: What Is the Approach of Austrian Practitioners?Animals : an open access journal from MDPI · 2024Article
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- Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection.Cell reports. Medicine · 2024Article
- Zoonotic and other veterinary chlamydiae - an update, the role of the plasmid and plasmid-mediated transformation.Pathogens and disease · 2024Review
- Carriage of antibiotic resistance genes to treatments for chlamydial disease in koalas (One health (Amsterdam, Netherlands) · 2023Article
- Extra Virgin Olive Oil-Based Formulations: A "Green" Strategy againstInternational journal of molecular sciences · 2023Article
- Phenotypic and Genotypic Antimicrobial Susceptibility Testing ofAntibiotics (Basel, Switzerland) · 2023Article
- Review
- The Effect of Amoxicillin Pre-Exposure on Treatment Outcomes and Antimicrobial Susceptibility in Patients with UrogenitalInfection and drug resistance · 2023Article
- Distribution of drug-resistant genes in alveolar lavage fluid from patients with psittacosis and traceability analysis of causative organisms.Frontiers in microbiology · 2023Article
- Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Antibiotics (Basel, Switzerland) · 2022Article
- Expansion of the pRAS3 Plasmid Family inAntibiotics (Basel, Switzerland) · 2022Article
- Article
- Animal Chlamydiae: A Concern for Human and Veterinary Medicine.Pathogens (Basel, Switzerland) · 2022Article
- Direct assessment of possible mutations in the 23S rRNA gene encoding macrolide resistance in Chlamydia trachomatis.PloS one · 2022Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Many strains of Chlamydia suis, a pathogen of pigs, express a stable tetracycline resistance phenotype. We demonstrate that this resistance pattern is associated with a resistance gene, tet(C), in the chlamydial chromosome. Four related genomic islands were identified in seven tetracycline-resistant C. suis strains. All resistant isolates carry the structural gene tet(C) and the tetracycline repressor gene tetR(C). The islands share significant nucleotide sequence identity with resistance plasmids carried by a variety of different bacterial species. Three of the four tet(C) islands also carry a novel insertion sequence that is homologous to the IS605 family of insertion sequences. In each strain, the resistance gene and associated sequences are recombined into an identical position in a gene homologous to the inv gene of the yersiniae. These genomic islands represent the first examples of horizontally acquired DNA integrated into a natural isolate of chlamydiae or within any other obligate intracellular bacterium.
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