ArticleAntimicrobial agents and chemotherapy2004
Mechanism of resistance to several antimicrobial agents in Salmonella Clinical isolates causing traveler's diarrhea.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Virulence factors and mechanisms of antimicrobial resistance in Shigella strains from periurban areas of Lima (Peru).International journal of medical microbiology : IJMMTrial
- Traditional marketed meats as a reservoir of multidrug-resistant Escherichia coli.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Occurrence and antimicrobial susceptibility of Salmonella enterica in milk along the supply chain, humans, and the environment in Woliata Sodo, Ethiopia.BMC microbiology · 2024Article
- Antibiotic Resistance in Bacteria-A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Klebsiella spp. cause severe and fatal disease in Mozambican children: antimicrobial resistance profile and molecular characterization.BMC infectious diseases · 2021Article
- Travel-Related Antimicrobial Resistance: A Systematic Review.Tropical medicine and infectious disease · 2021Review
- Transferable Mechanisms of Quinolone Resistance from 1998 Onward.Clinical microbiology reviews · 2019Review
- Carrion's Disease: the Sound of Silence.Clinical microbiology reviews · 2018Review
- Article
- Isolation, Identification, and Antibiotic Susceptibility Testing of Salmonella from Slaughtered Bovines and Ovines in Addis Ababa Abattoir Enterprise, Ethiopia: A Cross-Sectional Study.International journal of bacteriology · 2016Article
- Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong.BMC genomics · 2015Article
- Antibiotic resistance pattern among the Salmonella isolated from human, animal and meat in India.Tropical animal health and production · 2012Article
- Antimicrobial susceptibility and mechanisms of resistance in Shigella and Salmonella isolates from children under five years of age with diarrhea in rural Mozambique.Antimicrobial agents and chemotherapy · 2009Article
- [Imported infectious diseases in Spain].Medicina clinica · 2008Review
- Antimicrobial resistance genes associated with Salmonella enterica serovar newport isolates from food animals.Antimicrobial agents and chemotherapy · 2008Article
- SGI1-K, a variant of the SGI1 genomic island carrying a mercury resistance region, in Salmonella enterica serovar Kentucky.Antimicrobial agents and chemotherapy · 2007Article
- Gene cassette encoding a 3-N-aminoglycoside acetyltransferase in a chromosomal integron.Antimicrobial agents and chemotherapy · 2006Article
- Class 1 Integrons in Salmonella Strains causing traveler's diarrhea.Antimicrobial agents and chemotherapy · 2006Article
- Prevalence, serotyping and antimicrobials resistance mechanism of Salmonella enterica isolated from clinical and environmental samples in Saudi Arabia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of antimicrobial resistance in Salmonella isolates causing traveler's diarrhea (TD) and their mechanisms of resistance to several antimicrobial agents were analyzed. From 1995 to 2002, a total of 62 Salmonella strains were isolated from stools of patients with TD. The antimicrobial susceptibility to 12 antibiotics was determined, and the molecular mechanisms of resistance to several of them were detected as well. The highest levels of resistance were found against tetracycline and ampicillin (21 and 19%, respectively), followed by resistance to nalidixic acid (16%), which was mainly detected from 2000 onward. Molecular mechanisms of resistance were analyzed in 16 isolates. In these isolates, which were resistant to ampicillin, two genes encoding beta-lactamases were detected: oxa-1 (one isolate) and tem-like (seven isolates [in one strain concomitantly with a carb-2]). Resistance to tetracycline was mainly related to tetA (five cases) and to tetB and tetG (one case each). Resistance to chloramphenicol was related to the presence of the floR and cmlA genes and to chloramphenicol acetyltransferase activity in one case each. Different genes encoding dihydrofolate-reductases (dfrA1, dfrA12, dfrA14, and dfrA17) were detected in trimethoprim-resistant isolates. Resistance to nalidixic acid was related to the presence of mutations in the amino acid codons 83 or 87 of the gyrA gene. Further surveillance of the Salmonella spp. causing TD is needed to detect trends in their resistance to antimicrobial agents, as we have shown in our study with nalidixic acid. Moreover, such studies will lead to better treatment and strategies to prevent and limit their spread.
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