ArticleDigestive diseases and sciences2004
IL-10 gene therapy is therapeutic for dextran sodium sulfate-induced murine colitis.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Amelioration of Murine Colitis by AttenuatedMicroorganisms · 2023Article
- Hydroalcoholic Extract from Inflorescences ofEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models.Gastroenterology research and practice · 2015Review
- PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.Scientific reports · 2014Article
- Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis.BMC gastroenterology · 2014Article
- Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis.BMC gastroenterology · 2013Article
- Bolus injection of newly synthesized vitamin E derivative ETS-GS for the treatment of acute severe ulcerative colitis in a mouse model. New vitamin E derivative for acute severe UC.International journal of colorectal disease · 2013Article
- Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model.European journal of nutrition · 2012Article
- Non-condensing polymeric nanoparticles for targeted gene and siRNA delivery.International journal of pharmaceutics · 2012Review
- Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies.Inflammatory bowel diseases · 2011Review
- Interleukin-10 repletion suppresses pro-inflammatory cytokines and decreases liver pathology without altering viral replication in murine cytomegalovirus (MCMV)-infected IL-10 knockout mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Soybean and fish oil mixture increases IL-10, protects against DNA damage and decreases colonic inflammation in rats with dextran sulfate sodium (DSS) colitis.Lipids in health and disease · 2010Article
- A C-type lectin MGL1/CD301a plays an anti-inflammatory role in murine experimental colitis.The American journal of pathology · 2009Article
- Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease.Gene therapy · 2008Article
- Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5.Digestive diseases and sciences · 2008Article
- An angiotensin II receptor antagonist reduces inflammatory parameters in two models of colitis.Regulatory peptides · 2008Article
- Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target.Science (New York, N.Y.) · 2008Article
- Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats.BMC gastroenterology · 2006Article
- [Role of gene therapy in trauma and orthopedic surgery].Der Unfallchirurg · 2006Review
- The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games.Immunology · 2005Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transfer of genes encoding immunoregulatory proteins is a promising new strategy in the treatment of intestinal inflammation. Previous work has demonstrated that daily systemic interleukin (IL)-10 therapy is able to prevent disease onset in animal models of colitis but is not sufficient to treat established disease. This study investigates the therapeutic efficacy of an adenovirus encoding IL-10 (AdvmuIL-10) in the treatment of experimental colitis. Colitis was induced in BALB/c mice by the addition of dextran sodium sulfate to the drinking water for 7 days. A single systemic injection of AdvmuIL-10, empty cassette vector (Adv0), or saline vehicle was administered on day 4 after the onset of colitis. The addition of DSS to the drinking water led to an acute, dose-dependent colitis. A single injection of AdvmuIL-10 led to a marked reduction in both stool markers of inflammation (IL-1beta, IL-6, and TNFRII) and serum IL-6. Furthermore, the histological colitis score was significantly reduced in mice receiving AdvmuIL-10 compared to controls (4.9 +/- 1.1 Vs 9.1 +/- 1.2, respectively; P < 0.05). A single systemic injection of AdvmuIL-10 is therapeutic in mice with established DSS colitis. Gene therapy strategies using adenoviral vectors encoding IL-10 may prove to be a potent therapy for chronic inflammation of the colon such as Crohn's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.