ArticleDigestive diseases and sciences2004
Development of colorectal sensitization is associated with increased eosinophils and mast cells in dextran sulfate sodium-treated rats.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer.PloS one · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used conscious restrained rats, in which balloon distension of the colorectum was used as a repeated visceral stimulus over a 21-day period, either alone or in conjunction with a luminal irritant, dextran sodium sulfate (DSS), in order to elicit sensitization as evidenced by amplified blood pressure responses. Female Sprague Dawley rats received 5% DSS in the drinking water for 3 days. A water-filled balloon was used to distend the colorectum. Set volumes (1, 1.5, and 2 mL) were applied for 3 min, at 10-min intervals, weekly for 3 weeks, with colorectal and tail-cuff blood pressures measured. Tissue for mast cell localization and histology were taken from proximal and distal colon at sacrifice. Mean colorectal balloon pressures and blood pressures in the DSS-treated rats compared to controls were 12% (P < 0.01) and 64% (P < 0.03) higher, respectively. At sacrifice the DSS-treated rats had twice the number of mast cell numbers in the mucosa of the proximal colon compared to controls, suggesting that the sensitization effect may be linked to inflammatory mediators (P < 0.05).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.