Down's syndrome protects against breast cancer: is a constitutional cell microenvironment the key?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2.Science advances · 2024
   Article
2. Germline BRCA2 Pathogenic Variant in Primary Breast Cancer of a Down Syndrome Individual.The American journal of case reports · 2023
   Article
3. Ten Reasons Why People With Down Syndrome are Protected From the Development of Most Solid Tumors -A Review.Frontiers in genetics · 2021
   Review
4. iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome.Scientific reports · 2020
   Article
5. Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics.Human molecular genetics · 2020
   Article
6. Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer.Cancer research · 2011
   Article
7. Hypothesis: primary antiangiogenic method proposed to treat early stage breast cancer.BMC cancer · 2009
   Article
8. New concepts in breast cancer emerge from analyzing clinical data using numerical algorithms.International journal of environmental research and public health · 2009
   Article
9. Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.Molecular and cellular biology · 2008
   Article
10. Paradoxes in carcinogenesis: new opportunities for research directions.BMC cancer · 2007
    Article
11. Aspects of digestive tract tumors in Down syndrome: a literature review.Digestive diseases and sciences · 2006
    Review
12. Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins.RNA biology
    Article

Corrections and comments

• Comment on
  Tumor reversion: correction of malignant behavior by microenvironmental cues.2003

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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