ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 74 citations in OpenAlex.
- Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice.Molecular psychiatry · 2024Article
- BK ZERO isoform HEK293 stably transfected cell lines differing 3'UTRs to assess miR-9 regulation.PloS one · 2024Article
- miR-9 utilizes precursor pathways in adaptation to alcohol in mouse striatal neurons.Advances in drug and alcohol research · 2023Article
- Article
- Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders.Frontiers in neuroscience · 2018Review
- Review
- Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models.Pharmacogenomics · 2017Review
- Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- Modulation of BK Channels by Ethanol.International review of neurobiology · 2016Review
- Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons.Alcoholism, clinical and experimental research · 2015Article
- Alcohol withdrawal is associated with a downregulation of large-conductance Ca²⁺-activated K⁺ channels in rat inferior colliculus neurons.Psychopharmacology · 2014Article
- Ethanol-mediated relaxation of guinea pig urinary bladder smooth muscle: involvement of BK and L-type Ca2+ channels.American journal of physiology. Cell physiology · 2014Article
- Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior.Frontiers in physiology · 2014Review
- Neurochemical mechanisms of alcohol withdrawal.Handbook of clinical neurology · 2014Review
- Nicotine addiction reduces the large-conductance Ca(2+)-activated potassium channels expression in the nucleus accumbens.Neuromolecular medicine · 2013Article
- An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells.Frontiers in behavioral neuroscience · 2013Article
- A role for dynamin in triggering ethanol tolerance.Alcoholism, clinical and experimental research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Tolerance is an important element of drug addiction and provides a model for understanding neuronal plasticity. The hypothalamic-neurohypophysial system (HNS) is an established preparation in which to study the actions of alcohol. Acute application of alcohol to the rat neurohypophysis potentiates large-conductance calcium-sensitive potassium channels (BK), contributing to inhibition of hormone secretion. A cultured HNS explant from adult rat was used to explore the molecular mechanisms of BK tolerance after prolonged alcohol exposure. Ethanol tolerance was intrinsic to the HNS and consisted of: (1) decreased BK potentiation by ethanol, complete within 12 min of exposure, and (2) decreased current density, which was not complete until 24 hr after exposure, indicating that the two components of tolerance represent distinct processes. Single-channel properties were not affected by chronic exposure, suggesting that decreased current density resulted from downregulation of functional channels in the membrane. Indeed, we observed decreased immunolabeling against the BK alpha-subunit on the surface of tolerant terminals. Analysis using confocal microscopy revealed a reduction of BK channel clustering, likely associated with the internalization of the channel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.