ArticleInfection and immunity2004
Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Surveillance of Daughter Micronodule Formation Is a Key Factor for Vaccine Evaluation Using Experimental Infection Models of Tuberculosis in Macaques.Pathogens (Basel, Switzerland) · 2023Article
- The lymphatic vasculature in lung function and respiratory disease.Frontiers in medicine · 2023Review
- The guinea pig model for tick-borne spotted fever rickettsioses: A second look.Ticks and tick-borne diseases · 2020Review
- Lymph nodes-The neglected battlefield in tuberculosis.PLoS pathogens · 2020Review
- Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques.PLoS pathogens · 2018Article
- Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.Vaccine · 2013Article
- Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography.Antimicrobial agents and chemotherapy · 2012Article
- Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles.Advanced drug delivery reviews · 2011Review
- Article
- Visualization of abscess formation in a murine thigh infection model of Staphylococcus aureus by 19F-magnetic resonance imaging (MRI).PloS one · 2011Article
- Article
- Development of new vaccines and drugs for TB: limitations and potential strategic errors.Future microbiology · 2011Review
- Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.PloS one · 2010Article
- Evaluation of standard chemotherapy in the guinea pig model of tuberculosis.Antimicrobial agents and chemotherapy · 2010Article
- Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosis.Infection and immunity · 2009Article
- Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection.Tuberculosis (Edinburgh, Scotland) · 2008Article
- Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis.Clinical and vaccine immunology : CVI · 2008Article
- Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis.Clinical and experimental immunology · 2007Review
- Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.Infection and immunity · 2006Article
- The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We utilized magnetic resonance imaging to visualize lesions in the lungs of guinea pigs infected by low-dose aerosol exposure to Mycobacterium tuberculosis. Lesions were prominent in such images, and colorized three-dimensional reconstructions of images revealed a very uniform distribution in the lungs. Lesion numbers after 1 month were approximately similar to the aerosol exposure algorithm, suggesting that each was established by a single bacterium. Numbers of lesions in unprotected and vaccinated animals were similar over the first month but increased thereafter in the control animals, indicating secondary lesion development. Whereas lesion sizes increased progressively in control guinea pigs, lesions remained small in BCG-vaccinated animals. A prominent feature of the disease pathology in unprotected animals was rapid and severe lymphadenopathy of the mediastinal lymph node cluster, which is paradoxical given the strong state of cellular immunity at this time. Further development of this technical approach could be very useful in tracking lesion size, number, and progression in the search for new tuberculosis vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.