ArticleJournal of neurovirology2004
Identification of genes involved in the host response to enterovirus 71 infection.
Article in Journal of neurovirology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Biological characteristics of an enterovirus A71 subgroup C4 strain isolated in China.BMC infectious diseases · 2025Article
- IKKε isoform switching governs the immune response against EV71 infection.Communications biology · 2021Article
- Molecular determinants and heterogeneity underlying host response to EV-A71 infection at single-cell resolution.RNA biology · 2021Article
- Pim1 Impacts Enterovirus A71 Replication and Represents a Potential Target in Antiviral Therapy.iScience · 2019Article
- Transcriptomic analysis of cells in response to EV71 infection and 2AGenes & genomics · 2019Article
- Factors associated with fatal outcome of children with enterovirus A71 infection: a case series.Epidemiology and infection · 2018Observational
- Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein.Journal of virology · 2017Article
- Identification of genes involved in enterovirus 71 infected SK-N-SH cells.International journal of clinical and experimental pathology · 2017Article
- Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8.PLoS pathogens · 2014Article
- Article
- Enterovirus 71 induces mitochondrial reactive oxygen species generation that is required for efficient replication.PloS one · 2014Article
- Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71.BMC infectious diseases · 2013Article
- lncRNA expression signatures in response to enterovirus 71 infection.Biochemical and biophysical research communications · 2013Article
- Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection.PloS one · 2013Article
- Human IgG subclasses against enterovirus Type 71: neutralization versus antibody dependent enhancement of infection.PloS one · 2013Article
- A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor.Virology journal · 2012Article
- Host factors in enterovirus 71 replication.Journal of virology · 2011Review
- Viral kinetics of enterovirus 71 in human abdomyosarcoma cells.World journal of gastroenterology · 2011Article
- Article
- Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterovirus 71 (EV71) infection may be asymptomatic or may cause diarrhea, rashes, and hand, foot, and mouth disease (HFMD). However, EV71 also has the potential to cause severe neurological disease. To date, little is known about the molecular mechanisms of host response to EV71 infection. In this report, we utilized cDNA microarray to profile the kinetics and patterns of host gene expression in EV71-infected human neural SF268 cells. We have identified 157 genes with significant changes in mRNA expression and performed hierarchical clustering to classify these genes into five different groups based on their kinetics of expression. EV71 infection led to increases in the level of mRNAs encoding chemokines, proteins involved in protein degradation, complement proteins, and proapoptotis proteins. cDNA microarray expression comparisons of EV71- and mock-infected cells also revealed the down-regulation of several genes encoding proteins involved in host RNA synthesis. Expression of interferon-regulated proteins was increased early in the infection and then decreased. Expression of proteins involved in cellular development and differentiation, some oncogenes, and transcription and translation regulators were suppressed and then stimulated late in the infection. Our findings illustrate the overall host response to EV71 infection, and will aid in understanding the host response to this virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.