ArticleThe Journal of comparative neurology2004
Synaptic and extrasynaptic localization of brain-derived neurotrophic factor and the tyrosine kinase B receptor in cultured hippocampal neurons.
Article in The Journal of comparative neurology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Brain-derived neurotrophic factor scales presynaptic calcium transients to modulate excitatory neurotransmission.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons.Frontiers in molecular neuroscience · 2022Article
- BDNF Overexpression Enhances the Preconditioning Effect of Brief Episodes of Hypoxia, Promoting Survival of GABAergic Neurons.Neuroscience bulletin · 2020Article
- Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability.Brain structure & function · 2019Article
- Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.Neuropharmacology · 2018Article
- Colitis-induced bladder afferent neuronal activation is regulated by BDNF through PLCγ pathway.Experimental neurology · 2016Article
- Stochastic Subcellular Organization of Dense-Core Vesicles Revealed by Point Pattern Analysis.Biophysical journal · 2016Article
- BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors.Purinergic signalling · 2016Article
- Neurotrophin signaling and visceral hypersensitivity.Frontiers in biology · 2014Article
- BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons.Frontiers in synaptic neuroscience · 2014Article
- Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking.Developmental neurobiology · 2012Article
- Cell type-dependent trafficking of neuropeptide Y-containing dense core granules in CNS neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Ethanol alters BDNF-induced Rho GTPase activation in axonal growth cones.Alcoholism, clinical and experimental research · 2011Article
- Decoding BDNF-LTP coupling in cocaine addiction.Neuron · 2010Article
- Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons.PloS one · 2010Article
- Brain-derived neurotrophic factor and the development of structural neuronal connectivity.Developmental neurobiology · 2010Review
- Synaptic maturation of the Xenopus retinotectal system: effects of brain-derived neurotrophic factor on synapse ultrastructure.The Journal of comparative neurology · 2010Article
- BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses.Experimental brain research · 2009Review
- Nitric oxide alters GABAergic synaptic transmission in cultured hippocampal neurons.Brain research · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) regulates synapses, but the distribution of BDNF and its receptor TrkB relative to the location of glutamatergic and gamma-aminobutyric acidergic (GABAergic) synapses is presently unknown. Immunocytochemistry was performed in primary hippocampal neuron cultures to determine whether BDNF and TrkB are preferentially localized to excitatory or inhibitory markers at 7, 14, and 21 days in vitro (DIV). Glutamatergic sites were localized with vesicular glutamate transporter type 1 (VGLUT1) as presynaptic marker and the NR1 subunit of the NMDA receptor and the GluR1 subunit of the AMPA receptor as receptor markers. GABAergic sites were labeled with the 65-kDa isoform of glutamic acid decarboxylase (GAD-65) as presynaptic marker and the gamma2 subunit of the GABAA receptor as receptor marker. During development, <30% of BDNF punctae and TrkB clusters were localized to glutamatergic and GABAergic markers. Because their rates of colocalization did not change from 7 to 21 DIV, this study details the distribution of BDNF and TrkB at 14 DIV. BDNF was preferentially colocalized with glutamatergic markers VGLUT1 and NR1 ( approximately 30% each). TrkB was also relatively highly colocalized with VGLUT1 and NR1 ( approximately 20% each) but was additionally highly colocalized with GABAergic markers GAD-65 ( approximately 20%) and gamma2 ( approximately 30%). NR1 clusters colocalized with BDNF puncta and TrkB clusters were mostly extrasynaptic, as were gamma2 clusters colocalized with TrkB clusters. These results show that, whereas most BDNF and TrkB protein is extrasynaptic, BDNF is preferentially associated with excitatory markers and that TrkB is associated equally with excitatory and inhibitory markers.
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