ArticleJournal of molecular evolution2004
Covariation of mitochondrial genome size with gene lengths: evidence for gene length reduction during mitochondrial evolution.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- A Genome-Wide Analysis of Nuclear Mitochondrial DNA Sequences (NUMTs) in Chrysomelidae Species (Coleoptera).Insects · 2025Article
- Mitochondrial Genomes ofAnimals : an open access journal from MDPI · 2024Article
- Mitogenome of Coprophanaeus ensifer and phylogenetic analysis of the Scarabaeidae family (Coleoptera).Genetics and molecular biology · 2021Article
- Complete mitochondrial genomes of Trisidos kiyoni and Potiarca pilula: Varied mitochondrial genome size and highly rearranged gene order in Arcidae.Scientific reports · 2016Article
- Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.Genome biology and evolution · 2015Article
- The compact mitochondrial genome of Zorotypus medoensis provides insights into phylogenetic position of Zoraptera.BMC genomics · 2014Article
- Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation.Molecular biology of the cell · 2009Article
- Pentatricopeptide repeat proteins in Trypanosoma brucei function in mitochondrial ribosomes.Molecular and cellular biology · 2007Article
- Hitting the brakes: termination of mitochondrial transcription.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduction of genome size and gene shortening have been observed in a number of parasitic and mutualistic intracellular symbionts. Reduction of coding capacity is also a unifying principle in the evolutionary history of mitochondria, but little is known about the evolution of gene length in mitochondria. The genes for cytochrome c oxidase subunits I-III, cytochrome b, and the large and small subunit rRNAs are, with very few exceptions, always found on the mitochondrial genome. These resident mitochondrial genes can therefore be used to test whether the reduction in gene lengths observed in a number of intracellular symbionts is also seen in mitochondria. Here we show that resident mitochondrial gene products are shorter than their corresponding counterparts in alpha-proteobacteria and, furthermore, that the reduction of mitochondrial genome size is correlated with a reduction in the length of the corresponding resident gene products. We show that relative genomic AT content, which has been identified as a factor influencing gene lengths in other systems, cannot explain gene length/genome size covariance observed in mitochondria. Our data are therefore in agreement with the idea that gene length evolves as a consequence of selection for smaller genomes, either to avoid accumulation of deleterious mutations or triggered by selection for a replication advantage.
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